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NFKB1 nuclear factor kappa B subunit 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 461406, updated on 3-Apr-2024

Summary

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Official Symbol
NFKB1provided by VGNC
Official Full Name
nuclear factor kappa B subunit 1provided by VGNC
Primary source
VGNC:VGNC:2972
Locus tag
CK820_G0022237
See related
Ensembl:ENSPTRG00000016320
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 3 NC_072401.2 (103964358..104079626)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 4 NC_072402.1 (103964042..104079607)

Chromosome 3 - NC_072401.2Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 8 Neighboring gene zinc finger protein 705A-like Neighboring gene uncharacterized LOC107974357 Neighboring gene mannosidase beta Neighboring gene keratin, type II cytoskeletal 8-like Neighboring gene protein MANBAL-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear factor NF-kappa-B p105 subunit
Names
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072401.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    103964358..104079626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001168718.6 → XP_001168718.1  nuclear factor NF-kappa-B p105 subunit isoform X3

    See identical proteins and their annotated locations for XP_001168718.1

    UniProtKB/TrEMBL
    A0A2J8MAX1, A0A2J8MAY9, A0A6D2W202, H2QPY8
    Related
    ENSPTRP00000028033.2
    Conserved Domains (7) summary
    cd07935
    Location:43 → 244
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    COG0666
    Location:500 → 706
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:251 → 352
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:816 → 891
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:543 → 580
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:587 → 681
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:690 → 733
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_009448072.5 → XP_009446347.1  nuclear factor NF-kappa-B p105 subunit isoform X4

    See identical proteins and their annotated locations for XP_009446347.1

    UniProtKB/TrEMBL
    A0A2J8MAX5, A0A2J8MAY9, A0A803KIE4, K7DQM6
    Conserved Domains (7) summary
    cd07935
    Location:42 → 243
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    COG0666
    Location:499 → 705
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:250 → 351
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:815 → 890
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:542 → 579
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:586 → 680
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:689 → 732
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_016951926.4 → XP_016807415.1  nuclear factor NF-kappa-B p105 subunit isoform X1

    Conserved Domains (7) summary
    cd07935
    Location:51 → 252
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    cd00204
    Location:585 → 714
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01177
    Location:259 → 360
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:824 → 899
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:551 → 588
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:534 → 621
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:694 → 742
    Ank_4; Ankyrin repeats (many copies)

  4. XM_016951927.4 → XP_016807416.1  nuclear factor NF-kappa-B p105 subunit isoform X2

    Conserved Domains (8) summary
    cd07935
    Location:50 → 251
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    cd00204
    Location:584 → 713
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01177
    Location:258 → 359
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:823 → 898
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    pfam12796
    Location:594 → 688
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:551 → 610
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:678 → 734
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:550 → 587
    ANK; ANK repeat [structural motif]

  5. XM_063808978.1 → XP_063665048.1  nuclear factor NF-kappa-B p105 subunit isoform X7

  6. XM_054683229.2 → XP_054539204.1  nuclear factor NF-kappa-B p105 subunit isoform X5

  7. XM_063808977.1 → XP_063665047.1  nuclear factor NF-kappa-B p105 subunit isoform X6

Nucleotide Protein
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