Hmbs Hydroxymethylbilane synthase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hmbsprovided by FlyBase
Official Full Name: Hydroxymethylbilane synthaseprovided by FlyBase
Primary source: FLYBASE:FBgn0010786
Locus tag: Dmel_CG9165
See related: AllianceGenome:FB:FBgn0010786
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2640; 3544; anon-WO0153538.70; CG9165; Dmel\CG9165; l(3)02640; l(3)3544; l(3)7E130; l(3)j4E3; Pbgd; PBGD
Summary: Predicted to enable hydroxymethylbilane synthase activity. Predicted to be involved in heme biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval central nervous system; embryonic/larval digestive system; eye disc; nephrocyte; and ring gland. Human ortholog(s) of this gene implicated in acute intermittent porphyria and sickle cell anemia. Orthologous to human HMBS (hydroxymethylbilane synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1334889..1339415)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1334889..1339415)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables hydroxymethylbilane synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydroxymethylbilane synthase activity	IEA Inferred from Electronic Annotation more info
enables hydroxymethylbilane synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in tetrapyrrole biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

NP_612103.1

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The following sections contain reference sequences that belong to a specific genome build. Explain