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TEC tec protein tyrosine kinase [ Pan troglodytes (chimpanzee) ]

Gene ID: 461343, updated on 29-Mar-2024

Summary

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Official Symbol
TECprovided by VGNC
Official Full Name
tec protein tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:732
Locus tag
CK820_G0033389
See related
Ensembl:ENSPTRG00000016041
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 3 NC_072401.2 (82961679..83092978)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 4 NC_072402.1 (82961695..83098353)

Chromosome 3 - NC_072401.2Genomic Context describing neighboring genes Neighboring gene U6 snRNA-associated Sm-like protein LSm2 Neighboring gene SLAIN motif family member 2 Neighboring gene uncharacterized LOC134809798 Neighboring gene uncharacterized LOC134809799 Neighboring gene U6 spliceosomal RNA Neighboring gene TXK tyrosine kinase Neighboring gene NIPA like domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of platelet activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tissue regeneration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Tec
Names
transient erythroblastopenia of childhood
XP_016807269.2
XP_063664981.1
XP_063664982.1
XP_063664983.1
XP_517310.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072401.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    82961679..83092978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_517310.7 → XP_517310.3  tyrosine-protein kinase Tec isoform X3

    UniProtKB/TrEMBL
    A0A2I3S537, A0A2J8L327
    Conserved Domains (4) summary
    cd10396
    Location:240 → 346
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:182 → 237
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:365 → 624
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

  2. XM_063808913.1 → XP_063664983.1  tyrosine-protein kinase Tec isoform X4

  3. XM_016951780.4 → XP_016807269.2  tyrosine-protein kinase Tec isoform X5

    UniProtKB/TrEMBL
    A0A2I3S537
    Conserved Domains (4) summary
    cd10396
    Location:197 → 303
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:139 → 194
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 111
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:322 → 581
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

  4. XM_063808911.1 → XP_063664981.1  tyrosine-protein kinase Tec isoform X1

  5. XM_063808912.1 → XP_063664982.1  tyrosine-protein kinase Tec isoform X2

Nucleotide Protein
Heading Accession and Version

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