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KIT KIT proto-oncogene, receptor tyrosine kinase [ Pan troglodytes (chimpanzee) ]

Gene ID: 461316, updated on 3-Apr-2024

Summary

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Official Symbol
KITprovided by VGNC
Official Full Name
KIT proto-oncogene, receptor tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:6662
Locus tag
CK820_G0003210
See related
Ensembl:ENSPTRG00000016067
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 3 NC_072401.2 (75117043..75199833, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 4 NC_072402.1 (75117015..75199765, complement)

Chromosome 3 - NC_072401.2Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL38-like Neighboring gene uncharacterized LOC107974319 Neighboring gene uncharacterized LOC104006110 Neighboring gene platelet derived growth factor receptor alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mast/stem cell growth factor receptor Kit
Names
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
XP_009446157.1
XP_009446158.1
XP_009446159.1
XP_009446160.1
XP_016807214.1
XP_054539106.1
XP_054539108.1
XP_517285.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072401.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    75117043..75199833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_517285.8 → XP_517285.3  mast/stem cell growth factor receptor Kit isoform X5

    See identical proteins and their annotated locations for XP_517285.3

    UniProtKB/TrEMBL
    A0A2J8PEN0, A0A6D2XDN7, H2QPH5, H2RHI1, K7DFX7
    Related
    ENSPTRP00000027637.5
    Conserved Domains (4) summary
    cd05104
    Location:549 → 924
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 305
    ig; Immunoglobulin domain
    cd00096
    Location:426 → 505
    Ig; Immunoglobulin domain
    cd05860
    Location:311 → 411
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)

  2. XM_016951725.3 → XP_016807214.1  mast/stem cell growth factor receptor Kit isoform X7

    UniProtKB/TrEMBL
    A0A2J8PEL6, H2RHI1
    Conserved Domains (4) summary
    cd05104
    Location:549 → 923
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 305
    ig; Immunoglobulin domain
    cd00096
    Location:426 → 505
    Ig; Immunoglobulin domain
    cd05860
    Location:311 → 411
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)

  3. XM_054683131.1 → XP_054539106.1  mast/stem cell growth factor receptor Kit isoform X3

  4. XM_009447883.4 → XP_009446158.1  mast/stem cell growth factor receptor Kit isoform X1

    See identical proteins and their annotated locations for XP_009446158.1

    UniProtKB/TrEMBL
    A0A2J8PEL9, H2RHI1, K7CAF7
    Related
    ENSPTRP00000060983.2
    Conserved Domains (4) summary
    cd05104
    Location:553 → 928
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 305
    ig; Immunoglobulin domain
    cd00096
    Location:426 → 505
    Ig; Immunoglobulin domain
    cd05860
    Location:311 → 411
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)

  5. XM_054683133.1 → XP_054539108.1  mast/stem cell growth factor receptor Kit isoform X6

  6. XM_009447885.4 → XP_009446160.1  mast/stem cell growth factor receptor Kit isoform X4

    See identical proteins and their annotated locations for XP_009446160.1

    UniProtKB/TrEMBL
    H2RHI1
    Conserved Domains (6) summary
    cd00096
    Location:427 → 506
    Ig; Immunoglobulin domain
    cd05860
    Location:312 → 412
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220 → 308
    IG_like; Immunoglobulin like
    cd05104
    Location:550 → 925
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 306
    ig; Immunoglobulin domain
    pfam07714
    Location:586 → 921
    Pkinase_Tyr; Protein tyrosine kinase

  7. XM_009447884.4 → XP_009446159.1  mast/stem cell growth factor receptor Kit isoform X2

    UniProtKB/TrEMBL
    H2RHI1
    Conserved Domains (6) summary
    cd00096
    Location:427 → 506
    Ig; Immunoglobulin domain
    cd05860
    Location:312 → 412
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220 → 308
    IG_like; Immunoglobulin like
    cd05104
    Location:554 → 928
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 306
    ig; Immunoglobulin domain
    pfam07714
    Location:590 → 924
    Pkinase_Tyr; Protein tyrosine kinase

  8. XM_009447882.4 → XP_009446157.1  mast/stem cell growth factor receptor Kit isoform X8

    See identical proteins and their annotated locations for XP_009446157.1

    UniProtKB/TrEMBL
    H2RHI1
    Conserved Domains (6) summary
    cd00096
    Location:427 → 506
    Ig; Immunoglobulin domain
    cd05860
    Location:312 → 412
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220 → 308
    IG_like; Immunoglobulin like
    cd05104
    Location:554 → 929
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 306
    ig; Immunoglobulin domain
    pfam07714
    Location:590 → 925
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
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