DVL3 dishevelled segment polarity protein 3 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: DVL3provided by VGNC
Official Full Name: dishevelled segment polarity protein 3provided by VGNC
Primary source: VGNC:VGNC:1798
Locus tag: CK820_G0023366
See related: Ensembl:ENSPTRG00000015681
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as: PHKB
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	2	NC_086015.1 (187338753..187356560)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	3	NC_072401.1 (187248164..187265929)

Chromosome 2 - NC_086015.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

D3S4388 (e-PCR)
- UniSTS:474139

D3S4407 (e-PCR)
- UniSTS:474160

NoName (e-PCR)
- UniSTS:532277

Dvl3 (e-PCR), detects polymorphism
- UniSTS:532277

SHGC-77602 (e-PCR)
- UniSTS:13115

SHGC-77605 (e-PCR)
- UniSTS:53083

STS-R80399 (e-PCR)
- UniSTS:23916

1436 (e-PCR)
- UniSTS:5039

Dvl3 (e-PCR), detects polymorphism
- UniSTS:508380

RH77956 (e-PCR)
- UniSTS:11756

RH101840 (e-PCR)
- UniSTS:51709

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables frizzled binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in planar cell polarity pathway involved in neural tube closure	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: segment polarity protein dishevelled homolog DVL-3

Names: dishevelled, dsh homolog 3; phosphorylase kinase, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

187338753..187356560

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009446941.5 → XP_009445216.1 segment polarity protein dishevelled homolog DVL-3

See identical proteins and their annotated locations for XP_009445216.1

UniProtKB/TrEMBL

A0A2I3TV38

Conserved Domains (5) summary

smart00021
Location:1 → 82

DAX; Domain present in Dishevelled and axin

cd00992
Location:247 → 334

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:413 → 496

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:92 → 245

Dishevelled; Dishevelled specific domain

pfam12316
Location:500 → 706

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal