PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: PIK3CAprovided by VGNC
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:7083
Locus tag: CK820_G0032065
See related: Ensembl:ENSPTRG00000015642
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	2	NC_086015.1 (182330292..182418850)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	3	NC_072401.1 (182239682..182324427)

Chromosome 2 - NC_086015.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

SHGC-12912 (e-PCR)
- UniSTS:43777

RH41892 (e-PCR)
- UniSTS:26651

PIK3CA_4031 (e-PCR)
- UniSTS:462410

SHGC-77571 (e-PCR)
- UniSTS:2893

RH65632 (e-PCR)
- UniSTS:84057

GDB:596369 (e-PCR)
- UniSTS:158097

GDB:596374 (e-PCR)
- UniSTS:158098

RH70978 (e-PCR)
- UniSTS:19672

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	IEA Inferred from Electronic Annotation more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IB	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Names: phosphoinositide-3-kinase, catalytic, alpha polypeptide

XP_024211590.1

EC 2.7.1.153

XP_024211591.1

EC 2.7.1.153

XP_063663429.1

EC 2.7.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

182330292..182418850

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024355822.3 → XP_024211590.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A2I3T7A8, A0A2J8L760, A0A8I3B1D7, K7A3X0, K7BQ68

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_024355823.3 → XP_024211591.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A2I3T7A8, A0A2J8L760, A0A8I3B1D7, K7A3X0, K7BQ68

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_063807359.1 → XP_063663429.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A2J8L760, A0A8I3B1D7, K7A3X0, K7BQ68