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NCK1 NCK adaptor protein 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 460720, updated on 3-Apr-2024

Summary

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Official Symbol
NCK1provided by VGNC
Official Full Name
NCK adaptor protein 1provided by VGNC
Primary source
VGNC:VGNC:2438
Locus tag
CK820_G0030065
See related
Ensembl:ENSPTRG00000015434
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 2 NC_086015.1 (140090834..140177828)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 3 NC_072401.1 (140000308..140087195)

Chromosome 2 - NC_086015.1Genomic Context describing neighboring genes Neighboring gene STAG1 cohesin complex component Neighboring gene dnaJ homolog subfamily C member 8-like Neighboring gene RAD51-associated protein 1-like Neighboring gene solute carrier family 35 member G2 Neighboring gene uncharacterized LOC107970779 Neighboring gene interleukin 20 receptor subunit beta Neighboring gene mitochondrial carrier homolog 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of PERK-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SH2/SH3 adapter protein NCK1
Names
cytoplasmic protein NCK1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001246580.1 → NP_001233509.1  SH2/SH3 adapter protein NCK1

    See identical proteins and their annotated locations for NP_001233509.1

    Status: PROVISIONAL

    Source sequence(s)
    AK306244
    UniProtKB/TrEMBL
    A0A2I3RLD1, A0A2J8QJ43, A0A6D2WDF8, G2HHN0
    Related
    ENSPTRP00000026594.3, ENSPTRT00000028816.4
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    140090834..140177828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009446477.4 → XP_009444752.1  SH2/SH3 adapter protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_009444752.1

    UniProtKB/TrEMBL
    A0A2I3RLD1, A0A2J8QJ43, A0A6D2WDF8, G2HHN0
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  2. XM_063805190.1 → XP_063661260.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2J8QJ43, A0A6D2WDF8, G2HHN0

  3. XM_054680272.2 → XP_054536247.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2J8QJ43, A0A6D2WDF8, G2HHN0

  4. XM_063805191.1 → XP_063661261.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2J8QJ43, A0A6D2WDF8, G2HHN0

  5. XM_063805193.1 → XP_063661263.1  SH2/SH3 adapter protein NCK1 isoform X2

    UniProtKB/TrEMBL
    A0A2J8QJ57, A0A6D2WI89, K7CEM4

  6. XM_009446478.4 → XP_009444753.1  SH2/SH3 adapter protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_009444753.1

    UniProtKB/TrEMBL
    A0A2I3RLD1, A0A2J8QJ43, A0A6D2WDF8, G2HHN0
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  7. XM_063805192.1 → XP_063661262.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2J8QJ43, A0A6D2WDF8, G2HHN0
Nucleotide Protein
Heading Accession and Version

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