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Acsl Acyl-CoA synthetase long-chain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46068, updated on 27-Mar-2024

Summary

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Official Symbol
Acslprovided by FlyBase
Official Full Name
Acyl-CoA synthetase long-chainprovided by FlyBase
Primary source
FLYBASE:FBgn0263120
Locus tag
Dmel_CG8732
See related
AllianceGenome:FB:FBgn0263120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
7447; ACS; acsl; ACSL1; ACSL3; ACSL3/4; anon-WO0172774.173; CG8732; dAcsl; dFAC; Dmel\CG8732; FACS; FCS; l(2)05847; l(2)44DEa; l(2)7447; l(2)k05304; l(2)SH0465; l(2)SH2 0465
Summary
Enables palmitoyl-CoA ligase activity. Involved in several processes, including axon guidance; organophosphate biosynthetic process; and positive regulation of sequestering of triglyceride. Located in axon; endoplasmic reticulum; and peroxisome. Is expressed in several structures, including adult head; adult heart; and fat body. Used to study non-syndromic X-linked intellectual disability and non-syndromic X-linked intellectual disability 63. Human ortholog(s) of this gene implicated in asthma; breast cancer; intellectual disability; non-syndromic X-linked intellectual disability 63; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3) and ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
44E1-44E2; 2-59 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8665813..8683022)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4553318..4570527)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44281 Neighboring gene patched Neighboring gene transfer RNA:Leucine-CAG 1-1 Neighboring gene Ubiquinol-cytochrome c reductase 11 kDa subunit-like Neighboring gene uncharacterized protein Neighboring gene Jonah 44E Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An Integrated Transcriptomics and Lipidomics Analysis Reveals That Ergosterol Is Required for Host Defense Against Bacterial Infection in Drosophila. Deng Z, et al. Front Immunol, 2022. PMID 35874695, Free PMC Article
  2. Free fatty acid determination as a tool for modeling metabolic diseases in Drosophila. Sellin J, et al. J Insect Physiol, 2020 Oct. PMID 32730782
  3. Reticulon-like-1, the Drosophila orthologue of the hereditary spastic paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons. O'Sullivan NC, et al. Hum Mol Genet, 2012 Aug 1. PMID 22543973, Free PMC Article
  4. Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids. Huang Y, et al. J Cell Sci, 2016 Nov 1. PMID 27656110
  5. Listeria monocytogenes infection causes metabolic shifts in Drosophila melanogaster. Chambers MC, et al. PLoS One, 2012. PMID 23272066, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. novel insights into a critical and previously unappreciated role of Acsl in neurogenesis
    Title: Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation.
  2. Acsl inhibits neuromuscular junction growth.
    Title: Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids.
  3. our results reveal a novel mechanism whereby dAcsl facilitates Rab11-dependent receptor recycling and provide insights into the pathogenesis of ACSL4-related mental retardation
    Title: dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling.
  4. propose that Acsl plays a role in embryonic segmentation by shifting the anteroposterior boundaries of gap genes Kni and Hb
    Title: Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation.
  5. this study demonstrated that dAcsl regulates axonal transport of synaptic vesicles and is required for synaptic development and function.
    Title: Drosophila Acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission.
  6. ACSL4 can substitute the functions of dAcsl(l(2)44DEa in organismal viability, lipid storage and the neural wiring in visual center.
    Title: Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp/BMP production and visual wiring in the brain.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables palmitoyl-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in long-chain fatty-acyl-CoA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylglycerol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of sequestering of triglyceride IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in segmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Acyl-CoA synthetase long-chain
Names
Acsl-PA
Acsl-PB
Acsl-PC
Acsl-PD
Acsl-PE
Acsl-PF
Acsl-PG
Acsl-PH
Acsl-PI
Acsl-PJ
Acyl-CoAsynthetase long-chain
CG8732-PA
CG8732-PB
CG8732-PC
CG8732-PD
CG8732-PE
CG8732-PF
CG8732-PG
CG8732-PH
CG8732-PI
CG8732-PJ
Long-chain acyl-CoA synthetase
fatty acyl CoA synthetase
fatty acyl coenzyme A (CoA) synthetase
fatty acyl-CoA synthetase
lethal (2) 44DEa
lethal (2) SH0465
NP_001014507.1
NP_001014508.1
NP_001014509.1
NP_001014510.1
NP_001014511.1
NP_001014512.1
NP_001260810.1
NP_652034.2
NP_724695.1
NP_724696.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8665813..8683022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014511.2 → NP_001014511.1  Acyl-CoA synthetase long-chain, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014511.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS4, Q8T3L1, Q9V4W4
    Conserved Domains (2) summary
    cd05927
    Location:129 → 713
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:82 → 714
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  2. NM_170615.2 → NP_724695.1  Acyl-CoA synthetase long-chain, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724695.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS4, Q8T3L1, Q9V4W4
    Related
    FBpp0087779
    Conserved Domains (2) summary
    cd05927
    Location:129 → 713
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:82 → 714
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  3. NM_143777.3 → NP_652034.2  Acyl-CoA synthetase long-chain, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652034.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS4, Q8T3L1, Q9V4W4
    Related
    FBpp0087780
    Conserved Domains (2) summary
    cd05927
    Location:129 → 713
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:82 → 714
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  4. NM_001014512.2 → NP_001014512.1  Acyl-CoA synthetase long-chain, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014512.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H2, Q86NS4
    Conserved Domains (2) summary
    cd05927
    Location:131 → 715
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:84 → 716
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  5. NM_001014510.2 → NP_001014510.1  Acyl-CoA synthetase long-chain, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014510.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H3, Q86NS4
    Conserved Domains (2) summary
    cd05927
    Location:121 → 705
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:74 → 706
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  6. NM_001014508.2 → NP_001014508.1  Acyl-CoA synthetase long-chain, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014508.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS4, Q8T3L1, Q9V4W4
    Conserved Domains (2) summary
    cd05927
    Location:129 → 713
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:82 → 714
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  7. NM_001014509.2 → NP_001014509.1  Acyl-CoA synthetase long-chain, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014509.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H3, Q86NS4
    Conserved Domains (2) summary
    cd05927
    Location:121 → 705
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:74 → 706
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  8. NM_001273881.1 → NP_001260810.1  Acyl-CoA synthetase long-chain, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260810.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFE4, Q86NS4
    Conserved Domains (2) summary
    cd05927
    Location:142 → 726
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:95 → 727
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  9. NM_170616.2 → NP_724696.1  Acyl-CoA synthetase long-chain, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724696.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H3, Q86NS4
    Related
    FBpp0087781
    Conserved Domains (2) summary
    cd05927
    Location:121 → 705
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:74 → 706
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

  10. NM_001014507.2 → NP_001014507.1  Acyl-CoA synthetase long-chain, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014507.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H3, Q86NS4
    Conserved Domains (2) summary
    cd05927
    Location:121 → 705
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:74 → 706
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFE4 A0A0B4KFE4
A1Z7H2 A1Z7H2
A1Z7H3 A1Z7H3
Q8T3L1 Q8T3L1
Q960I0 Q960I0

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