APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: APPL1provided by VGNC
Official Full Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1provided by VGNC
Primary source: VGNC:VGNC:8730
Locus tag: CK820_G0004898
See related: Ensembl:ENSPTRG00000015045
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	2	NC_086015.1 (61248077..61298097)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	3	NC_072401.1 (61247758..61293073)

Chromosome 2 - NC_086015.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D8S2279 (e-PCR)
- UniSTS:473907

D3S2814E (e-PCR)
- UniSTS:150850

D11S3114 (e-PCR)
- UniSTS:152207

SHGC-77071 (e-PCR)
- UniSTS:4301

RH99000 (e-PCR)
- UniSTS:83920

G38326 (e-PCR)
- UniSTS:6873

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase B binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signaling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DCC-interacting protein 13-alpha

Names: adaptor protein containing pH domain, PTB domain and leucine zipper motif; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

61248077..61298097

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063805894.1 → XP_063661964.1 DCC-interacting protein 13-alpha isoform X1

UniProtKB/TrEMBL

A0A2J8P7W8, A0A6D2VSL3, H2QMU0
XM_001173707.8 → XP_001173707.1 DCC-interacting protein 13-alpha isoform X1

See identical proteins and their annotated locations for XP_001173707.1

UniProtKB/TrEMBL

A0A2I3T5P6, A0A2J8P7W8, A0A6D2VSL3, H2QMU0

Related

ENSPTRP00000025987.3

Conserved Domains (3) summary

cd07631
Location:20 → 234

BAR_APPL1; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 1

cd13158
Location:490 → 625

PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain

cd13247
Location:252 → 376

BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
XM_054682013.2 → XP_054537988.1 DCC-interacting protein 13-alpha isoform X5
XM_063805897.1 → XP_063661967.1 DCC-interacting protein 13-alpha isoform X4
XM_063805896.1 → XP_063661966.1 DCC-interacting protein 13-alpha isoform X3
XM_063805895.1 → XP_063661965.1 DCC-interacting protein 13-alpha isoform X3
XM_016941360.4 → XP_016796849.1 DCC-interacting protein 13-alpha isoform X7

UniProtKB/TrEMBL

A0A2I3T5P6
XM_063805899.1 → XP_063661969.1 DCC-interacting protein 13-alpha isoform X8
XM_016941358.4 → XP_016796847.1 DCC-interacting protein 13-alpha isoform X2

UniProtKB/TrEMBL

A0A2I3T5P6
XM_063805898.1 → XP_063661968.1 DCC-interacting protein 13-alpha isoform X6