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RAF1 Raf-1 proto-oncogene, serine/threonine kinase [ Pan troglodytes (chimpanzee) ]

Gene ID: 460182, updated on 3-Apr-2024

Summary

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Official Symbol
RAF1provided by VGNC
Official Full Name
Raf-1 proto-oncogene, serine/threonine kinaseprovided by VGNC
Primary source
VGNC:VGNC:12161
Locus tag
CK820_G0008765
See related
Ensembl:ENSPTRG00000014635
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 2 NC_086015.1 (16592754..16673165, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 3 NC_072401.1 (16592426..16672645, complement)

Chromosome 2 - NC_086015.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene MKRN2 opposite strand Neighboring gene makorin ring finger protein 2 Neighboring gene small nucleolar RNA U13 Neighboring gene transmembrane protein 40 Neighboring gene keratin, type I cytoskeletal 18-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
RAF proto-oncogene serine/threonine-protein kinase
Names
v-raf-1 murine leukemia viral oncogene homolog 1
XP_009443195.1
XP_009443196.1
XP_009443197.1
XP_016795984.1
XP_016795985.1
XP_016795986.1
XP_054537468.1
XP_054537469.1
XP_054537470.1
XP_054537471.1
XP_063662681.1
XP_063662682.1
XP_063662683.1
XP_063662684.1
XP_063662685.1
XP_063662686.1
XP_516289.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    16592754..16673165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054681493.2 → XP_054537468.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    H2QM30, K7DGA2

  2. XM_063806612.1 → XP_063662682.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

  3. XM_516289.8 → XP_516289.2  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_516289.2

    UniProtKB/TrEMBL
    A0A2I3THL4, H2QM30, K7DGA2
    Related
    ENSPTRP00000025252.5
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  4. XM_016940496.3 → XP_016795985.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A2I3THL4, H2QM30, K7DGA2
    Related
    ENSPTRP00000088719.1
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  5. XM_009444922.4 → XP_009443197.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    See identical proteins and their annotated locations for XP_009443197.1

    Conserved Domains (3) summary
    cd14149
    Location:222 → 504
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00069
    Location:236 → 491
    Pkinase; Protein kinase domain
    pfam00130
    Location:58 → 106
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  6. XM_009444921.4 → XP_009443196.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    See identical proteins and their annotated locations for XP_009443196.1

    UniProtKB/TrEMBL
    A0A2I3THL4
    Conserved Domains (2) summary
    cd14149
    Location:255 → 537
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  7. XM_009444920.4 → XP_009443195.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    See identical proteins and their annotated locations for XP_009443195.1

    UniProtKB/TrEMBL
    A0A2I3THL4
    Conserved Domains (4) summary
    cd01816
    Location:57 → 131
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:303 → 585
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00069
    Location:317 → 572
    Pkinase; Protein kinase domain
    pfam00130
    Location:139 → 187
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  8. XM_016940497.3 → XP_016795986.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A2I3THL4
    Conserved Domains (2) summary
    cd14149
    Location:255 → 537
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  9. XM_054681496.2 → XP_054537471.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

  10. XM_063806613.1 → XP_063662683.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

  11. XM_054681494.2 → XP_054537469.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    H2QM30, K7DGA2

  12. XM_063806615.1 → XP_063662685.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

  13. XM_054681495.2 → XP_054537470.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

  14. XM_063806616.1 → XP_063662686.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

  15. XM_016940495.3 → XP_016795984.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A2I3THL4, H2QM30, K7DGA2
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  16. XM_063806611.1 → XP_063662681.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    H2QM30, K7DGA2

  17. XM_063806614.1 → XP_063662684.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

Nucleotide Protein
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