IRS1 insulin receptor substrate 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: IRS1provided by VGNC
Official Full Name: insulin receptor substrate 1provided by VGNC
Primary source: VGNC:VGNC:1981
Locus tag: CK820_G0010956
See related: Ensembl:ENSPTRG00000012989
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2B

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	13	NC_072411.2 (128973164..129041631, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	2B	NC_072400.1 (128884325..128951683, complement)

Chromosome 13 - NC_072411.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

G65724 (e-PCR)
- UniSTS:225541

WI-18042 (e-PCR)
- UniSTS:11534

RH48158 (e-PCR)
- UniSTS:70162

SHGC-52849 (e-PCR)
- UniSTS:10265

GDB:456117 (e-PCR)
- UniSTS:157470

GDB:456125 (e-PCR)
- UniSTS:157472

RH17903 (e-PCR)
- UniSTS:46669

RH48420 (e-PCR)
- UniSTS:64081

SHGC-154923 (e-PCR)
- UniSTS:183397

D2S2647 (e-PCR)
- UniSTS:57707

PMC86565P4 (e-PCR)
- UniSTS:273537

IRS1_760 (e-PCR)
- UniSTS:277390

IRS1_V113 (e-PCR)
- UniSTS:277390

RH69408 (e-PCR)
- UniSTS:68843

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin receptor substrate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072411.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

128973164..129041631 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003309496.6 → XP_003309544.1 insulin receptor substrate 1

See identical proteins and their annotated locations for XP_003309544.1

UniProtKB/TrEMBL

A0A2J8NFK7, A0A6D2WIP8, H2QJJ4, K7D5X7

Conserved Domains (2) summary

cd01204
Location:160 → 263

PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)

cd01257
Location:11 → 118

PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
XM_009444442.5 → XP_009442717.1 insulin receptor substrate 1

See identical proteins and their annotated locations for XP_009442717.1

UniProtKB/TrEMBL

A0A2J8NFK7, A0A6D2WIP8, H2QJJ4, K7D5X7

Related

ENSPTRP00000022194.3

Conserved Domains (2) summary

cd01204
Location:160 → 263

PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)

cd01257
Location:11 → 118

PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain