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CFLAR CASP8 and FADD like apoptosis regulator [ Pan troglodytes (chimpanzee) ]

Gene ID: 459872, updated on 3-Apr-2024

Summary

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Official Symbol
CFLARprovided by VGNC
Official Full Name
CASP8 and FADD like apoptosis regulatorprovided by VGNC
Primary source
VGNC:VGNC:133
Locus tag
CK820_G0014820
See related
Ensembl:ENSPTRG00000012798
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2B
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 13 NC_072411.2 (103146499..103194960)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2B NC_072400.1 (103146462..103203501)

Chromosome 13 - NC_072411.2Genomic Context describing neighboring genes Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene uncharacterized LOC134808063 Neighboring gene inosine-5'-monophosphate dehydrogenase 1-like Neighboring gene U7 small nuclear RNA Neighboring gene large ribosomal subunit protein eL38-like Neighboring gene caspase 10 Neighboring gene caspase 8 Neighboring gene flagellum associated containing coiled-coil domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CASP8 and FADD-like apoptosis regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072411.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    103146499..103194960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003949939.6 → XP_003949988.1  CASP8 and FADD-like apoptosis regulator isoform X4

    See identical proteins and their annotated locations for XP_003949988.1

    UniProtKB/TrEMBL
    A0A2I3SPU3, A0A2I3SYK0, A0A2J8N545, A0A6D2VX85
    Related
    ENSPTRP00000082055.1
    Conserved Domains (3) summary
    smart00115
    Location:244 → 479
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:1 → 80
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91 → 171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

  2. XM_054679207.2 → XP_054535182.1  CASP8 and FADD-like apoptosis regulator isoform X5

    UniProtKB/TrEMBL
    A0A2I3SEG4, A0A2J8N541, A0A6D2X702

  3. XM_054679201.2 → XP_054535176.1  CASP8 and FADD-like apoptosis regulator isoform X1

  4. XM_054679210.2 → XP_054535185.1  CASP8 and FADD-like apoptosis regulator isoform X8

    UniProtKB/TrEMBL
    A0A2I3SD93, A0A2J8N513, A0A6D2W6R5

  5. XM_063791523.1 → XP_063647593.1  CASP8 and FADD-like apoptosis regulator isoform X9

    UniProtKB/TrEMBL
    A0A2I3RDI7, A0A2J8N521, A0A6D2XZ80

  6. XM_063791522.1 → XP_063647592.1  CASP8 and FADD-like apoptosis regulator isoform X9

    UniProtKB/TrEMBL
    A0A2I3RDI7, A0A2J8N521, A0A6D2XZ80

  7. XM_009443977.5 → XP_009442252.1  CASP8 and FADD-like apoptosis regulator isoform X4

    See identical proteins and their annotated locations for XP_009442252.1

    UniProtKB/TrEMBL
    A0A2I3SPU3, A0A2I3SYK0, A0A2J8N545, A0A6D2VX85
    Conserved Domains (3) summary
    smart00115
    Location:244 → 479
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:1 → 80
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91 → 171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

  8. XM_063791514.1 → XP_063647584.1  CASP8 and FADD-like apoptosis regulator isoform X2

  9. XM_054679202.2 → XP_054535177.1  CASP8 and FADD-like apoptosis regulator isoform X1

  10. XM_054679208.2 → XP_054535183.1  CASP8 and FADD-like apoptosis regulator isoform X5

    UniProtKB/TrEMBL
    A0A2I3SEG4, A0A2J8N541, A0A6D2X702

  11. XM_063791515.1 → XP_063647585.1  CASP8 and FADD-like apoptosis regulator isoform X3

  12. XM_063791519.1 → XP_063647589.1  CASP8 and FADD-like apoptosis regulator isoform X6

    UniProtKB/TrEMBL
    A0A2J8N532, A0A6D2WQ42, H2R695

  13. XM_063791520.1 → XP_063647590.1  CASP8 and FADD-like apoptosis regulator isoform X7

  14. XM_063791521.1 → XP_063647591.1  CASP8 and FADD-like apoptosis regulator isoform X8

    UniProtKB/TrEMBL
    A0A2I3SD93, A0A2J8N513, A0A6D2W6R5

  15. XM_063791526.1 → XP_063647596.1  CASP8 and FADD-like apoptosis regulator isoform X10

  16. XM_063791517.1 → XP_063647587.1  CASP8 and FADD-like apoptosis regulator isoform X4

    UniProtKB/TrEMBL
    A0A2I3SPU3, A0A2J8N545, A0A6D2VX85

  17. XM_063791525.1 → XP_063647595.1  CASP8 and FADD-like apoptosis regulator isoform X9

    UniProtKB/TrEMBL
    A0A2I3RDI7, A0A2J8N521, A0A6D2XZ80

  18. XM_063791518.1 → XP_063647588.1  CASP8 and FADD-like apoptosis regulator isoform X5

    UniProtKB/TrEMBL
    A0A2I3SEG4, A0A2J8N541, A0A6D2X702

  19. XM_054679203.2 → XP_054535178.1  CASP8 and FADD-like apoptosis regulator isoform X1

  20. XM_063791516.1 → XP_063647586.1  CASP8 and FADD-like apoptosis regulator isoform X4

    UniProtKB/TrEMBL
    A0A2I3SPU3, A0A2J8N545, A0A6D2VX85

  21. XM_063791524.1 → XP_063647594.1  CASP8 and FADD-like apoptosis regulator isoform X9

    UniProtKB/TrEMBL
    A0A2I3RDI7, A0A2J8N521, A0A6D2XZ80

  22. XM_063791527.1 → XP_063647597.1  CASP8 and FADD-like apoptosis regulator isoform X10

  23. XM_063791528.1 → XP_063647598.1  CASP8 and FADD-like apoptosis regulator isoform X10

Nucleotide Protein
Heading Accession and Version

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