BUB1 BUB1 mitotic checkpoint serine/threonine kinase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: BUB1provided by VGNC
Official Full Name: BUB1 mitotic checkpoint serine/threonine kinaseprovided by VGNC
Primary source: VGNC:VGNC:177
Locus tag: CK820_G0048667
See related: Ensembl:ENSPTRG00000012348
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2A

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	12	NC_072410.2 (12587263..12628404, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	2A	NC_072399.1 (109858031..109911727)

Chromosome 12 - NC_072410.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

BUB1_8234 (e-PCR)
- UniSTS:467589

AFMa037yb9 (e-PCR)
- UniSTS:24989

151XD12 (e-PCR)
- UniSTS:52162

D2S1888 (e-PCR), detects polymorphism
- UniSTS:82133

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in meiotic sister chromatid cohesion, centromeric	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mitotic checkpoint serine/threonine-protein kinase BUB1

Names: BUB1 budding uninhibited by benzimidazoles 1 homolog; budding uninhibited by benzimidazoles 1 homolog

XP_515685.4

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072410.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

12587263..12628404 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_515685.8 → XP_515685.4 mitotic checkpoint serine/threonine-protein kinase BUB1

UniProtKB/TrEMBL

A0A2J8JCW9, K7D3R8

Conserved Domains (2) summary

smart00777
Location:5 → 125

Mad3_BUB1_I; Mad3/BUB1 hoMad3/BUB1 homology region 1

cd14028
Location:786 → 1073

STKc_Bub1_vert; Catalytic domain of the Serine/Threonine kinase, Vertebrate Spindle assembly checkpoint protein Bub1