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SOCS5 suppressor of cytokine signaling 5 [ Pan troglodytes (chimpanzee) ]

Gene ID: 459209, updated on 11-Apr-2024

Summary

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Official Symbol
SOCS5provided by VGNC
Official Full Name
suppressor of cytokine signaling 5provided by VGNC
Primary source
VGNC:VGNC:10771
Locus tag
CK820_G0028044
See related
Ensembl:ENSPTRG00000040283
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2A
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 12 NC_072410.2 (75933524..75997657, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2A NC_072399.1 (46855588..46926562)

Chromosome 12 - NC_072410.2Genomic Context describing neighboring genes Neighboring gene multiple coagulation factor deficiency 2, ER cargo receptor complex subunit Neighboring gene uncharacterized LOC741170 Neighboring gene uncharacterized LOC134807917 Neighboring gene CXXC repeat containing interactor of PDZ3 domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
suppressor of cytokine signaling 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072410.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    75933524..75997657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016948481.3 → XP_016803970.1  suppressor of cytokine signaling 5

    UniProtKB/TrEMBL
    A0A2J8LL94, A0A6D2Y2M4, H2RII6
    Related
    ENSPTRP00000061344.1
    Conserved Domains (3) summary
    cd03739
    Location:479 → 534
    SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
    pfam12610
    Location:146 → 195
    SOCS; Suppressor of cytokine signalling
    cl15255
    Location:370 → 470
    SH2; Src homology 2 (SH2) domain

  2. XM_016948480.3 → XP_016803969.1  suppressor of cytokine signaling 5

    UniProtKB/TrEMBL
    A0A2J8LL94, A0A6D2Y2M4, H2RII6
    Conserved Domains (3) summary
    cd03739
    Location:479 → 534
    SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
    pfam12610
    Location:146 → 195
    SOCS; Suppressor of cytokine signalling
    cl15255
    Location:370 → 470
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein
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