EPAS1 endothelial PAS domain protein 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: EPAS1provided by VGNC
Official Full Name: endothelial PAS domain protein 1provided by VGNC
Primary source: VGNC:VGNC:244
Locus tag: CK820_G0028031
See related: Ensembl:ENSPTRG00000011891
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2A

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	12	NC_072410.2 (76322056..76411394, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	2A	NC_072399.1 (46441855..46531179)

Chromosome 12 - NC_072410.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

RH120495 (e-PCR)
- UniSTS:133660

D2S288 (e-PCR), detects polymorphism
- UniSTS:57394

RH16555 (e-PCR)
- UniSTS:82783

G20740 (e-PCR)
- UniSTS:59750

A006E13 (e-PCR)
- UniSTS:59751

RH122462 (e-PCR)
- UniSTS:135334

Epas1 (e-PCR), detects polymorphism
- UniSTS:499132

STS-M78744 (e-PCR)
- UniSTS:67522

SHGC-33342 (e-PCR)
- UniSTS:46788

D2S1715E (e-PCR)
- UniSTS:150744

D2S246E (e-PCR)
- UniSTS:473077

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: endothelial PAS domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072410.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

76322056..76411394 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001147219.7 → XP_001147219.1 endothelial PAS domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_001147219.1

UniProtKB/TrEMBL

A0A2I3TA92, A0A2J8LL81, A0A6D2VU71, H2QHV1

Related

ENSPTRP00000020413.4

Conserved Domains (5) summary

smart00091
Location:86 → 147

PAS; PAS domain

cd00083
Location:12 → 68

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam08778
Location:833 → 869

HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain

pfam08447
Location:254 → 341

PAS_3; PAS fold

pfam11413
Location:518 → 549

HIF-1; Hypoxia-inducible factor-1
XM_054677824.2 → XP_054533799.1 endothelial PAS domain-containing protein 1 isoform X2