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ADAM17 ADAM metallopeptidase domain 17 [ Pan troglodytes (chimpanzee) ]

Gene ID: 459018, updated on 29-Mar-2024

Summary

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Official Symbol
ADAM17provided by VGNC
Official Full Name
ADAM metallopeptidase domain 17provided by VGNC
Primary source
VGNC:VGNC:6
Locus tag
CK820_G0009836
See related
Ensembl:ENSPTRG00000011640
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2A
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 12 NC_072410.2 (113321860..113389267)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2A NC_072399.1 (9463971..9531314, complement)

Chromosome 12 - NC_072410.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134807946 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC134807947 Neighboring gene uncharacterized LOC134807949 Neighboring gene isoamyl acetate hydrolyzing esterase 1 (putative) Neighboring gene cleavage and polyadenylation specific factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 17
Names
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
XP_016802294.2
XP_054534207.1
XP_054534208.1
XP_063646194.1
XP_063646195.1
XP_515293.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072410.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    113321860..113389267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_515293.9 → XP_515293.4  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    A0A2J8NM15, K7CGK9
    Conserved Domains (4) summary
    smart00050
    Location:484 → 560
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:223 → 477
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:56 → 152
    Pep_M12B_propep; Reprolysin family propeptide
    pfam16698
    Location:581 → 641
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  2. XM_063790125.1 → XP_063646195.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X3

  3. XM_016946805.4 → XP_016802294.2  disintegrin and metalloproteinase domain-containing protein 17 isoform X2

    UniProtKB/TrEMBL
    K7CGK9
    Conserved Domains (3) summary
    smart00050
    Location:345 → 421
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:84 → 338
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam16698
    Location:442 → 502
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  4. XM_063790124.1 → XP_063646194.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X3

  5. XM_054678232.2 → XP_054534207.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X4

  6. XM_054678233.1 → XP_054534208.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X5

RNA

  1. XR_010149632.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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