EP300 E1A binding protein p300 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: EP300provided by VGNC
Official Full Name: E1A binding protein p300provided by VGNC
Primary source: VGNC:VGNC:5978
Locus tag: CK820_G0027542
See related: Ensembl:ENSPTRG00000014418
Gene type: protein coding
RefSeq status: INFERRED
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	23	NC_086016.1 (43086617..43176571)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	22	NC_072420.1 (36119012..36208966)

Chromosome 23 - NC_086016.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH46342 (e-PCR)
- UniSTS:48221

RH136048 (e-PCR)
- UniSTS:210043

D22S1541 (e-PCR)
- UniSTS:67472

A009U19 (e-PCR)
- UniSTS:43409

RH65941 (e-PCR)
- UniSTS:21415

PMC113761P2 (e-PCR)
- UniSTS:270253

G32842 (e-PCR)
- UniSTS:117421

EP300_8165 (e-PCR)
- UniSTS:467671

STS-N57495 (e-PCR)
- UniSTS:71650

SGC38348 (e-PCR)
- UniSTS:73462

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: histone acetyltransferase p300

NP_001231599.2

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244670.3 → NP_001231599.2 histone acetyltransferase p300

Status: INFERRED

Source sequence(s)

JAQQLN020000023

UniProtKB/TrEMBL

A0A2J8LN73, A0A803KJM4, H2QLS0, K7CIV1

Related

ENSPTRP00000024841.5, ENSPTRT00000026944.5

Conserved Domains (11) summary

cd05495
Location:1051 → 1158

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1729 → 1807

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1668 → 1708

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1170 → 1242

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15646
Location:1243 → 1277

PHD_p300; PHD finger found in histone acetyltransferase p300

pfam02172
Location:566 → 646

KIX; KIX domain

pfam02135
Location:347 → 414

zf-TAZ; TAZ zinc finger

pfam08214
Location:1306 → 1612

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2005 → 2097

Creb_binding; Creb binding

pfam09606
Location:1984 → 2405

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25526
Location:961 → 1064

TonB_N; TonB N-terminal region