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TIMP3 TIMP metallopeptidase inhibitor 3 [ Pan troglodytes (chimpanzee) ]

Gene ID: 458784, updated on 29-Mar-2024

Summary

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Official Symbol
TIMP3provided by VGNC
Official Full Name
TIMP metallopeptidase inhibitor 3provided by VGNC
Primary source
VGNC:VGNC:5998
Locus tag
CK820_G0024614
See related
Ensembl:ENSPTRG00000014292 Ensembl:ENSPTRG00000046424
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 23 NC_086016.1 (34902404..34964042)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 22 NC_072420.1 (27934800..27996438)

Chromosome 23 - NC_086016.1Genomic Context describing neighboring genes Neighboring gene BPI fold containing family C Neighboring gene uncharacterized LOC134809745 Neighboring gene F-box protein 7 Neighboring gene synapsin III Neighboring gene uncharacterized LOC107970234 Neighboring gene uncharacterized LOC134809717 Neighboring gene LARGE xylosyl- and glucuronyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to cytokine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
metalloproteinase inhibitor 3
Names
TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)
tissue inhibitor of metalloproteinase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_086016.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    34902404..34964042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_515097.8 → XP_515097.2  metalloproteinase inhibitor 3

    See identical proteins and their annotated locations for XP_515097.2

    UniProtKB/TrEMBL
    A0A2J8QP97, A0A6D2WU49, H2QLJ7
    Related
    ENSPTRP00000024612.4
    Conserved Domains (1) summary
    cd03585
    Location:24 → 200
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...
Nucleotide Protein
Heading Accession and Version

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