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ITGB2 integrin subunit beta 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 458607, updated on 3-Apr-2024

Summary

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Official Symbol
ITGB2provided by VGNC
Official Full Name
integrin subunit beta 2provided by VGNC
Primary source
VGNC:VGNC:3734
Locus tag
CK820_G0022987
See related
Ensembl:ENSPTRG00000013993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 22 NC_072420.2 (45531915..45578033, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 21 NC_072419.1 (43184667..43219488, complement)

Chromosome 22 - NC_072420.2Genomic Context describing neighboring genes Neighboring gene small ubiquitin like modifier 3 Neighboring gene PTTG1 interacting protein Neighboring gene uncharacterized LOC100614323 Neighboring gene uncharacterized protein encoded by LINC01547 Neighboring gene SLX9 ribosome biogenesis factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs). Walter NA, et al. J Theor Biol, 2005 Feb 7. PMID 15572059

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin beta-2
Names
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034122.1 → NP_001029294.1  integrin beta-2 precursor

    See identical proteins and their annotated locations for NP_001029294.1

    Status: PROVISIONAL

    Source sequence(s)
    AF340067
    UniProtKB/TrEMBL
    A0A2J8M8M2, A0A2J8M8P3, A0A663D7W1, Q5NKT5
    Related
    ENSPTRP00000055015.2, ENSPTRT00000062457.3
    Conserved Domains (3) summary
    smart00187
    Location:32 → 447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622 → 699
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:726 → 767
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072420.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    45531915..45578033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063803345.1 → XP_063659415.1  integrin beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8M8M2, A0A663D7W1, Q5NKT5

  2. XM_063803346.1 → XP_063659416.1  integrin beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8M8M2, A0A663D7W1, Q5NKT5

  3. XM_063803344.1 → XP_063659414.1  integrin beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8M8M2, A0A663D7W1, Q5NKT5

  4. XM_016938394.4 → XP_016793883.1  integrin beta-2 isoform X2

    UniProtKB/TrEMBL
    A0A2J8M8P3
Nucleotide Protein
Heading Accession and Version

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