PCK1 phosphoenolpyruvate carboxykinase 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: PCK1provided by VGNC
Official Full Name: phosphoenolpyruvate carboxykinase 1provided by VGNC
Primary source: VGNC:VGNC:6228
Locus tag: CK820_G0048814
See related: Ensembl:ENSPTRG00000013664
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	21	NC_072419.2 (63852538..63857890)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	20	NC_072418.1 (63908011..63913382)

Chromosome 21 - NC_072419.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

RH64136 (e-PCR)
- UniSTS:25176

Pck1 (e-PCR), detects polymorphism
- UniSTS:461927

SHGC-1372 (e-PCR)
- UniSTS:29838

PCK1__5838 (e-PCR)
- UniSTS:463781

SHGC-35332 (e-PCR)
- UniSTS:11485

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables manganese ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphoenolpyruvate carboxykinase (GTP) activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glycerol biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hepatocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in propionate catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to starvation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Names: cytosolic phosphoenolpyruvate carboxykinase 1; phosphoenolpyruvate carboxykinase 1 (soluble)

XP_009435729.1

EC 4.1.1.32

XP_514745.2

EC 4.1.1.32

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072419.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

63852538..63857890

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_514745.9 → XP_514745.2 phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1

UniProtKB/TrEMBL

A0A2J8JCD0, A0A6D2Y8T2, H2QKN1

Related

ENSPTRP00000023500.2

Conserved Domains (1) summary

cd00819
Location:27 → 615

PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...
XM_009437454.4 → XP_009435729.1 phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2

Conserved Domains (1) summary

cd00819
Location:4 → 483

PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...