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HNF4A hepatocyte nuclear factor 4 alpha [ Pan troglodytes (chimpanzee) ]

Gene ID: 458269, updated on 29-Mar-2024

Summary

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Official Symbol
HNF4Aprovided by VGNC
Official Full Name
hepatocyte nuclear factor 4 alphaprovided by VGNC
Primary source
VGNC:VGNC:14476
Locus tag
CK820_G0020045
See related
Ensembl:ENSPTRG00000013519
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 21 NC_072419.2 (50609070..50687008)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 20 NC_072418.1 (50664562..50742500)

Chromosome 21 - NC_072419.2Genomic Context describing neighboring genes Neighboring gene fat storage inducing transmembrane protein 2 Neighboring gene uncharacterized LOC107970030 Neighboring gene R3H domain containing like Neighboring gene uncharacterized LOC104003591 Neighboring gene large ribosomal subunit protein eL43-like Neighboring gene alpha tocopherol transfer protein like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hepatocyte nuclear factor 4-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072419.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    50609070..50687008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024352259.2 → XP_024208027.1  hepatocyte nuclear factor 4-alpha isoform X3

    UniProtKB/TrEMBL
    A0A2I3RX32, A0A2I3T080, A0A2J8MKF0, A0A6D2XJR6
    Conserved Domains (2) summary
    cd06931
    Location:129 → 351
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:38 → 113
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  2. XM_024352260.2 → XP_024208028.1  hepatocyte nuclear factor 4-alpha isoform X4

    UniProtKB/TrEMBL
    A0A2I3T080, A0A2J8MKE9
    Conserved Domains (2) summary
    cd06931
    Location:129 → 351
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:38 → 113
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  3. XM_016937951.3 → XP_016793440.1  hepatocyte nuclear factor 4-alpha isoform X1

    UniProtKB/TrEMBL
    A0A2I3TE66, A0A2J8MKD5, A0A6D2W5Q0, H2QKE3
    Related
    ENSPTRP00000087554.1
    Conserved Domains (2) summary
    cd06931
    Location:151 → 373
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60 → 135
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  4. XM_016937952.3 → XP_016793441.1  hepatocyte nuclear factor 4-alpha isoform X2

    UniProtKB/TrEMBL
    A0A2J8MKD6, H2QKE3
    Conserved Domains (2) summary
    cd06931
    Location:151 → 373
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60 → 135
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  5. XM_016937954.4 → XP_016793443.1  hepatocyte nuclear factor 4-alpha isoform X6

    UniProtKB/TrEMBL
    H2QKE3

  6. XM_016937953.3 → XP_016793442.1  hepatocyte nuclear factor 4-alpha isoform X5

Nucleotide Protein
Heading Accession and Version

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