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PLCG1 phospholipase C gamma 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 458253, updated on 3-Apr-2024

Summary

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Official Symbol
PLCG1provided by VGNC
Official Full Name
phospholipase C gamma 1provided by VGNC
Primary source
VGNC:VGNC:6244
Locus tag
CK820_G0020103
See related
Ensembl:ENSPTRG00000013500
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 21 NC_072419.2 (47404239..47443317)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 20 NC_072418.1 (47459731..47498808)

Chromosome 21 - NC_072419.2Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene DNA topoisomerase I Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene cholinephosphotransferase 1-like Neighboring gene acireductone dioxygenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Names
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
XP_009435516.1
XP_024207925.1
XP_054530866.1
XP_054530867.1
XP_063658576.1
XP_063658577.1
XP_063658578.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072419.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    47404239..47443317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009437241.4 → XP_009435516.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

    UniProtKB/TrEMBL
    A0A2I3SBS3
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1250
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    pfam00169
    Location:71 → 142
    PH; PH domain
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

  2. XM_054674891.2 → XP_054530866.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2

    UniProtKB/TrEMBL
    A0A2J8MKL3, A0A8I3B357, K7AR46, K7C8S5

  3. XM_024352157.3 → XP_024207925.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3

    UniProtKB/TrEMBL
    A0A2I3SBS3, A0A2J8MKL4, A0A6D2Y7K8, H2QKD0
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16214
    Location:156 → 306
    EFh_PI-PLCgamma1; EF-hand motif found in phosphoinositide phospholipase C gamma 1 (PI-PLC-gamma1)
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

  4. XM_054674892.1 → XP_054530867.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3

    UniProtKB/TrEMBL
    A0A2J8MKL4, A0A6D2Y7K8, H2QKD0

  5. XM_063802506.1 → XP_063658576.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2

    UniProtKB/TrEMBL
    A0A2J8MKL3, A0A8I3B357, K7AR46, K7C8S5

  6. XM_063802507.1 → XP_063658577.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

  7. XM_063802508.1 → XP_063658578.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3

    UniProtKB/TrEMBL
    A0A2J8MKL4, A0A6D2Y7K8, H2QKD0
Nucleotide Protein
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