HCK HCK proto-oncogene, Src family tyrosine kinase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: HCKprovided by VGNC
Official Full Name: HCK proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source: VGNC:VGNC:10154
Locus tag: CK820_G0048911
See related: Ensembl:ENSPTRG00000013371
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	21	NC_072419.2 (38271909..38321324)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	20	NC_072418.1 (38304110..38353056)

Chromosome 21 - NC_072419.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

D20S512E (e-PCR)
- UniSTS:150311

D20S727 (e-PCR)
- UniSTS:62512

SGC34341 (e-PCR)
- UniSTS:45621

RH92890 (e-PCR)
- UniSTS:90960

RH45427 (e-PCR)
- UniSTS:81800

HCK_3380 (e-PCR)
- UniSTS:462236

AL031189 (e-PCR)
- UniSTS:21946

G09843 (e-PCR)
- UniSTS:65997

SHGC-112528 (e-PCR)
- UniSTS:168682

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase HCK

Names: hemopoietic cell kinase

XP_016793145.1

EC 2.7.10.2

XP_016793146.1

EC 2.7.10.2

XP_016793147.1

EC 2.7.10.2

XP_016793148.1

EC 2.7.10.2

XP_063658883.1

EC 2.7.10.2

XP_063658884.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072419.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

38271909..38321324

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063802814.1 → XP_063658884.1 tyrosine-protein kinase HCK isoform X4

UniProtKB/TrEMBL

A0A2J8PYZ2
XM_016937657.3 → XP_016793146.1 tyrosine-protein kinase HCK isoform X2

UniProtKB/TrEMBL

A0A2J8PYX8, A0A2J8PYY4, A0A6D2XBY9, H2QK59

Related

ENSPTRP00000022925.5

Conserved Domains (3) summary

cd10363
Location:119 → 222

SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK

cl17036
Location:61 → 116

SH3; Src Homology 3 domain superfamily

cl21453
Location:233 → 503

PKc_like; Protein Kinases, catalytic domain
XM_063802813.1 → XP_063658883.1 tyrosine-protein kinase HCK isoform X2

UniProtKB/TrEMBL

A0A2J8PYY4
XM_016937659.3 → XP_016793148.1 tyrosine-protein kinase HCK isoform X4

UniProtKB/TrEMBL

A0A2J8PYY5, A0A2J8PYZ2

Conserved Domains (3) summary

cd10363
Location:118 → 221

SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK

cl17036
Location:60 → 115

SH3; Src Homology 3 domain superfamily

cl21453
Location:232 → 502

PKc_like; Protein Kinases, catalytic domain
XM_016937656.3 → XP_016793145.1 tyrosine-protein kinase HCK isoform X1

UniProtKB/TrEMBL

A0A2J8PYX8, A0A6D2XBY9, H2QK59
XM_016937658.3 → XP_016793147.1 tyrosine-protein kinase HCK isoform X3

UniProtKB/TrEMBL

A0A2J8PYY5