PSEN2 presenilin 2 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: PSEN2provided by VGNC
Official Full Name: presenilin 2provided by VGNC
Primary source: VGNC:VGNC:1474
Locus tag: CK820_G0040513
See related: Ensembl:ENSPTRG00000002052
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	1	NC_072398.2 (22396373..22422023, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	1	NC_072398.1 (208901550..208926964)

Chromosome 1 - NC_072398.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

D1S3685E (e-PCR)
- UniSTS:474204

D1S3686E (e-PCR)
- UniSTS:474205

PSEN2_2369 (e-PCR)
- UniSTS:280931

SHGC-35541 (e-PCR)
- UniSTS:38313

RH80332 (e-PCR)
- UniSTS:85946

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables aspartic endopeptidase activity, intramembrane cleaving	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in amyloid precursor protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in amyloid-beta metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein processing	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in ciliary rootlet	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: presenilin-2

Names: presenilin 2 (Alzheimer disease 4)

XP_001142009.2

EC 3.4.23.-

XP_009439853.1

EC 3.4.23.-

XP_009439855.1

EC 3.4.23.-

XP_063647357.1

EC 3.4.23.-

XP_063647359.1

EC 3.4.23.-

XP_063647361.1

EC 3.4.23.-

XP_063647362.1

EC 3.4.23.-

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

22396373..22422023 complement

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GenBank, FASTA, Sequence Viewer (Graphics)