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DVL1 dishevelled segment polarity protein 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 457191, updated on 29-Mar-2024

Summary

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Official Symbol
DVL1provided by VGNC
Official Full Name
dishevelled segment polarity protein 1provided by VGNC
Primary source
VGNC:VGNC:10606
Locus tag
CK820_G0053710
See related
Ensembl:ENSPTRG00000000025
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as
DSH; DVL-1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 1 NC_072398.2 (230622032..230636234)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 1 NC_072398.1 (663215..677418, complement)

Chromosome 1 - NC_072398.2Genomic Context describing neighboring genes Neighboring gene aurora kinase A interacting protein 1 Neighboring gene matrix remodeling associated 8 Neighboring gene taste 1 receptor member 3 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene uncharacterized LOC134807638

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Dorus S, et al. Cell, 2004 Dec 29. PMID 15620360
  2. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables frizzled binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in planar cell polarity pathway involved in neural tube closure IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
segment polarity protein dishevelled homolog DVL-1
Names
DSH homolog 1
dishevelled-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012430.1 → NP_001012432.1  segment polarity protein dishevelled homolog DVL-1

    See identical proteins and their annotated locations for NP_001012432.1

    Status: PROVISIONAL

    Source sequence(s)
    AY665280
    UniProtKB/Swiss-Prot
    Q5IS48
    UniProtKB/TrEMBL
    A0A2J8IRR3, A0A663DEY2, K7ANK8, K7CTR2
    Related
    ENSPTRP00000055553.3, ENSPTRT00000064008.3
    Conserved Domains (5) summary
    smart00021
    Location:1 → 85
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:392 → 474
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251 → 336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90 → 247
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:478 → 660
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    230622032..230636234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016958290.4 → XP_016813779.1  segment polarity protein dishevelled homolog DVL-1 isoform X1

    UniProtKB/TrEMBL
    A0A2J8IRS3, K7CTR2
    Conserved Domains (5) summary
    smart00021
    Location:1 → 85
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:417 → 499
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251 → 336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90 → 247
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:503 → 685
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  2. XM_016958250.3 → XP_016813739.1  segment polarity protein dishevelled homolog DVL-1 isoform X2

    UniProtKB/TrEMBL
    K7CTR2
    Conserved Domains (5) summary
    smart00021
    Location:1 → 85
    DAX; Domain present in Dishevelled and axin
    cd04438
    Location:417 → 499
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam00595
    Location:251 → 336
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02377
    Location:90 → 247
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:503 → 571
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5IS48.1 GenPept UniProtKB/Swiss-Prot:Q5IS48

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