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VAV3 vav guanine nucleotide exchange factor 3 [ Pan troglodytes (chimpanzee) ]

Gene ID: 457076, updated on 3-Apr-2024

Summary

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Official Symbol
VAV3provided by VGNC
Official Full Name
vav guanine nucleotide exchange factor 3provided by VGNC
Primary source
VGNC:VGNC:1722
Locus tag
CK820_G0023765
See related
Ensembl:ENSPTRG00000001024
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See VAV3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 1 NC_072398.2 (123365351..123767016)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 1 NC_072398.1 (107532268..107933933, complement)

Chromosome 1 - NC_072398.2Genomic Context describing neighboring genes Neighboring gene mitochondrial adenyl nucleotide antiporter SLC25A24-like Neighboring gene neuroblastoma breakpoint family member 6-like Neighboring gene solute carrier family 25 member 24 Neighboring gene uncharacterized LOC134808870 Neighboring gene uncharacterized LOC107973983 Neighboring gene cytochrome c oxidase subunit NDUFA4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide exchange factor VAV3
Names
vav 3 guanine nucleotide exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    123365351..123767016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016923622.3 → XP_016779111.2  guanine nucleotide exchange factor VAV3 isoform X4

    UniProtKB/TrEMBL
    A0A2J8M4E8, H2PZI8
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:514 → 561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18 → 103
    CAMSAP_CH; CAMSAP CH domain

  2. XM_016923599.4 → XP_016779088.2  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A2I3REC5, A0A2J8M4F7
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:819 → 874
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:514 → 561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18 → 103
    CAMSAP_CH; CAMSAP CH domain

  3. XM_016923612.4 → XP_016779101.2  guanine nucleotide exchange factor VAV3 isoform X3

    UniProtKB/TrEMBL
    A0A2I3REC5
    Conserved Domains (7) summary
    cd10407
    Location:642 → 744
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:795 → 850
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:572 → 633
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:514 → 561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18 → 103
    CAMSAP_CH; CAMSAP CH domain

  4. XM_016923606.4 → XP_016779095.2  guanine nucleotide exchange factor VAV3 isoform X2

    UniProtKB/TrEMBL
    A0A2I3REC5
    Conserved Domains (7) summary
    cd10407
    Location:643 → 745
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:796 → 851
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:573 → 634
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:491 → 538
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:193 → 357
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:360 → 483
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18 → 103
    CAMSAP_CH; CAMSAP CH domain

  5. XM_016923630.4 → XP_016779119.2  guanine nucleotide exchange factor VAV3 isoform X5

    UniProtKB/TrEMBL
    A0A2I3REC5
    Conserved Domains (7) summary
    cd10407
    Location:627 → 729
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:780 → 835
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:557 → 618
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:475 → 522
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:154 → 330
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:344 → 467
    PH_Vav; Vav pleckstrin homology (PH) domain
    cl00030
    Location:18 → 68
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  6. XM_054685413.2 → XP_054541388.1  guanine nucleotide exchange factor VAV3 isoform X6

Nucleotide Protein
Heading Accession and Version

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