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EPS15 epidermal growth factor receptor pathway substrate 15 [ Pan troglodytes (chimpanzee) ]

Gene ID: 456850, updated on 3-Apr-2024

Summary

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Official Symbol
EPS15provided by VGNC
Official Full Name
epidermal growth factor receptor pathway substrate 15provided by VGNC
Primary source
VGNC:VGNC:536
Locus tag
CK820_G0010657
See related
Ensembl:ENSPTRG00000000729
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 1 NC_072398.2 (179497621..179665373)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 1 NC_072398.1 (51633114..51801668, complement)

Chromosome 1 - NC_072398.2Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 9 Neighboring gene calreticulin-like Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene 26S proteasome non-ATPase regulatory subunit 7-like Neighboring gene tetratricopeptide repeat domain 39A Neighboring gene small ribosomal subunit protein uS5-like Neighboring gene ring finger protein 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor substrate 15

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    179497621..179665373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009457686.5 → XP_009455961.1  epidermal growth factor receptor substrate 15 isoform X6

    See identical proteins and their annotated locations for XP_009455961.1

    UniProtKB/TrEMBL
    A0A2I3RDS0, A0A2J8NIH2, A0A2J8NIH6, A0A6D2VSE8, A0A6D2WEI4, H2PZ06
    Related
    ENSPTRP00000001250.3
    Conserved Domains (2) summary
    smart00027
    Location:121 → 215
    EH; Eps15 homology domain
    COG1196
    Location:333 → 500
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_009457692.5 → XP_009455967.1  epidermal growth factor receptor substrate 15 isoform X7

    UniProtKB/TrEMBL
    A0A2I3RDS0, A0A2J8NIH2, A0A6D2WEI4
    Conserved Domains (5) summary
    smart00027
    Location:188 → 283
    EH; Eps15 homology domain
    cd00052
    Location:198 → 263
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:373 → 479
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12329
    Location:366 → 435
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    pfam16043
    Location:305 → 471
    DUF4795; Domain of unknown function (DUF4795)

  3. XM_009457667.5 → XP_009455942.1  epidermal growth factor receptor substrate 15 isoform X1

    UniProtKB/TrEMBL
    A0A2I3RDS0, A0A2J8NIH2, A0A6D2WEI4
    Conserved Domains (5) summary
    smart00027
    Location:121 → 215
    EH; Eps15 homology domain
    cd00052
    Location:265 → 330
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:440 → 546
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12329
    Location:433 → 502
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    pfam16043
    Location:372 → 538
    DUF4795; Domain of unknown function (DUF4795)

  4. XM_009457675.5 → XP_009455950.1  epidermal growth factor receptor substrate 15 isoform X3

    UniProtKB/TrEMBL
    A0A2I3RDS0, A0A2J8NIH2, A0A6D2WEI4
    Related
    ENSPTRP00000062814.1
    Conserved Domains (2) summary
    smart00027
    Location:121 → 215
    EH; Eps15 homology domain
    COG1196
    Location:370 → 537
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_009457698.5 → XP_009455973.1  epidermal growth factor receptor substrate 15 isoform X11

    Conserved Domains (5) summary
    smart00027
    Location:121 → 215
    EH; Eps15 homology domain
    cd00052
    Location:265 → 330
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:440 → 546
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12329
    Location:433 → 502
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    pfam16043
    Location:372 → 538
    DUF4795; Domain of unknown function (DUF4795)

  6. XM_009457679.5 → XP_009455954.1  epidermal growth factor receptor substrate 15 isoform X5

    UniProtKB/TrEMBL
    A0A2I3RDS0, A0A2J8NIH2, A0A6D2WEI4
    Conserved Domains (5) summary
    smart00027
    Location:121 → 215
    EH; Eps15 homology domain
    cd00052
    Location:228 → 293
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:403 → 509
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12329
    Location:396 → 465
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    pfam16043
    Location:335 → 501
    DUF4795; Domain of unknown function (DUF4795)

  7. XM_054666873.2 → XP_054522848.1  epidermal growth factor receptor substrate 15 isoform X13

  8. XM_054666865.2 → XP_054522840.1  epidermal growth factor receptor substrate 15 isoform X10

  9. XM_054666876.2 → XP_054522851.1  epidermal growth factor receptor substrate 15 isoform X14

  10. XM_054666871.2 → XP_054522846.1  epidermal growth factor receptor substrate 15 isoform X12

  11. XM_024345727.3 → XP_024201495.1  epidermal growth factor receptor substrate 15 isoform X2

    Conserved Domains (3) summary
    smart00027
    Location:107 → 201
    EH; Eps15 homology domain
    pfam03528
    Location:355 → 738
    Rabaptin
    cl25732
    Location:356 → 523
    SMC_N; RecF/RecN/SMC N terminal domain

  12. XM_054666857.2 → XP_054522832.1  epidermal growth factor receptor substrate 15 isoform X4

  13. XM_054666860.2 → XP_054522835.1  epidermal growth factor receptor substrate 15 isoform X8

  14. XM_063780432.1 → XP_063636502.1  epidermal growth factor receptor substrate 15 isoform X9

  15. XM_063780479.1 → XP_063636549.1  epidermal growth factor receptor substrate 15 isoform X16

  16. XM_009457705.4 → XP_009455980.1  epidermal growth factor receptor substrate 15 isoform X15

    Conserved Domains (5) summary
    smart00027
    Location:76 → 172
    EH; Eps15 homology domain
    cd00052
    Location:87 → 152
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:262 → 368
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12329
    Location:255 → 324
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    pfam16043
    Location:194 → 360
    DUF4795; Domain of unknown function (DUF4795)

  17. XM_063780476.1 → XP_063636546.1  epidermal growth factor receptor substrate 15 isoform X16

  18. XM_016918175.4 → XP_016773664.1  epidermal growth factor receptor substrate 15 isoform X15

    Conserved Domains (5) summary
    smart00027
    Location:76 → 172
    EH; Eps15 homology domain
    cd00052
    Location:87 → 152
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:262 → 368
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12329
    Location:255 → 324
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    pfam16043
    Location:194 → 360
    DUF4795; Domain of unknown function (DUF4795)
Nucleotide Protein
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