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TGFB1 transforming growth factor beta 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 456060, updated on 29-Mar-2024

Summary

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Official Symbol
TGFB1provided by VGNC
Official Full Name
transforming growth factor beta 1provided by VGNC
Primary source
VGNC:VGNC:2232
Locus tag
CK820_G0030509
See related
Ensembl:ENSPTRG00000011021
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 20 NC_072418.2 (44330912..44377700, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 19 NC_072417.1 (44330938..44376829, complement)

Chromosome 20 - NC_072418.2Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily S member 1 Neighboring gene AXL receptor tyrosine kinase Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene coiled-coil domain containing 97 Neighboring gene transmembrane protein 91 Neighboring gene B9 domain containing 2 Neighboring gene exosome component 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transforming growth factor beta-1; transforming growth factor beta-1 proprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072418.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    44330912..44377700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054674102.2 → XP_054530077.1  transforming growth factor beta-1 proprotein isoform X1

  2. XM_063801723.1 → XP_063657793.1  transforming growth factor beta-1 proprotein isoform X2

  3. XM_512687.8 → XP_512687.2  transforming growth factor beta-1 proprotein isoform X4

    See identical proteins and their annotated locations for XP_512687.2

    UniProtKB/TrEMBL
    A0A2J8QGC9, A0A6D2XHV7, H2QGE0
    Related
    ENSPTRP00000018930.5
    Conserved Domains (2) summary
    cd19384
    Location:292 → 390
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 261
    TGFb_propeptide; TGF-beta propeptide

  4. XM_009435655.5 → XP_009433930.1  transforming growth factor beta-1 proprotein isoform X3

    See identical proteins and their annotated locations for XP_009433930.1

    Conserved Domains (2) summary
    cd19384
    Location:293 → 391
    TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
    pfam00688
    Location:30 → 262
    TGFb_propeptide; TGF-beta propeptide
Nucleotide Protein
Heading Accession and Version

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