NOTCH3 notch receptor 3 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: NOTCH3provided by VGNC
Official Full Name: notch receptor 3provided by VGNC
Primary source: VGNC:VGNC:2302
Locus tag: CK820_G0026256
See related: Ensembl:ENSPTRG00000010617
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	20	NC_072418.2 (17851851..17893139, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	19	NC_072417.1 (17851893..17893181, complement)

Chromosome 20 - NC_072418.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

NOTCH3_362 (e-PCR)
- UniSTS:277536

D19S923 (e-PCR), detects polymorphism
- UniSTS:34863

PMC122602P1 (e-PCR)
- UniSTS:270400

SHGC-57293 (e-PCR)
- UniSTS:52587

G62127 (e-PCR)
- UniSTS:139187

D19S1009 (e-PCR)
- UniSTS:20959

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Notch binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of developmental process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neurogenic locus notch homolog protein 3

Names: notch 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072418.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

17851851..17893139 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009434909.4 → XP_009433184.1 neurogenic locus notch homolog protein 3 isoform X2

UniProtKB/TrEMBL

A0A2I3RYA8

Conserved Domains (10) summary

COG0666
Location:1725 → 1841

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00054
Location:158 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00204
Location:1814 → 1940

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00066
Location:1373 → 1407

Notch; LNR domain

pfam06816
Location:1456 → 1505

NOD; NOTCH protein

pfam07684
Location:1526 → 1585

NODP; NOTCH protein

pfam11936
Location:2160 → 2221

DUF3454; Domain of unknown function (DUF3454)

pfam12796
Location:1858 → 1950

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:1806 → 1861

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1853 → 1884

ANK; ANK repeat [structural motif]
XM_003316164.5 → XP_003316212.1 neurogenic locus notch homolog protein 3 isoform X1

See identical proteins and their annotated locations for XP_003316212.1

UniProtKB/TrEMBL

A0A2I3RYA8, A0A2J8LUC3, A0A6D2Y6I9, H2QFL8

Related

ENSPTRP00000018116.3

Conserved Domains (9) summary

smart00004
Location:1421 → 1458

NL; Domain found in Notch and Lin-12

cd00054
Location:158 → 195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00204
Location:1866 → 1992

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:1905 → 1936

ANK; ANK repeat [structural motif]

pfam00066
Location:1385 → 1418

Notch; LNR domain

pfam06816
Location:1508 → 1557

NOD; NOTCH protein

pfam07684
Location:1578 → 1637

NODP; NOTCH protein

pfam11936
Location:2212 → 2273

DUF3454; Domain of unknown function (DUF3454)

cl26464
Location:2045 → 2318

Atrophin-1; Atrophin-1 family