LDLR low density lipoprotein receptor [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: LDLRprovided by VGNC
Official Full Name: low density lipoprotein receptorprovided by VGNC
Primary source: VGNC:VGNC:2325
Locus tag: CK820_G0026496
See related: Ensembl:ENSPTRG00000010490
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	20	NC_072418.2 (13814830..13858382)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	19	NC_072417.1 (13814744..13858425)

Chromosome 20 - NC_072418.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

L17688 (e-PCR)
- UniSTS:74509

GDB:434012 (e-PCR)
- UniSTS:157204

RH66831 (e-PCR)
- UniSTS:2842

GDB:185228 (e-PCR)
- UniSTS:155436

D1S1423 (e-PCR)
- UniSTS:149619

GDB:186840 (e-PCR)
- UniSTS:155509

GDB:178396 (e-PCR)
- UniSTS:155005

D19S1126 (e-PCR)
- UniSTS:59528

GDB:181559 (e-PCR)
- UniSTS:155285

G44338 (e-PCR)
- UniSTS:95125

GDB:597677 (e-PCR)
- UniSTS:158106

GDB:187708 (e-PCR)
- UniSTS:155567

GDB:181630 (e-PCR)
- UniSTS:155317

G60299 (e-PCR)
- UniSTS:137404

GDB:371455 (e-PCR)
- UniSTS:156863

GDB:177082 (e-PCR)
- UniSTS:154829

GDB:631903 (e-PCR)
- UniSTS:158440

GDB:631909 (e-PCR)
- UniSTS:158441

PMC137182P7 (e-PCR)
- UniSTS:270828

PMC137182P8 (e-PCR)
- UniSTS:270829

PMC311069P3 (e-PCR)
- UniSTS:272884

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables lipoprotein particle binding	IEA Inferred from Electronic Annotation more info	PubMed
enables low-density lipoprotein particle receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in receptor-mediated endocytosis involved in cholesterol transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: low-density lipoprotein receptor

Names: low density lipoprotein receptor (familial hypercholesterolemia)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072418.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

13814830..13858382

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024351165.3 → XP_024206933.1 low-density lipoprotein receptor isoform X1

UniProtKB/TrEMBL

A0A2J8LW13, A0A8I3B336, K7BZX3, K7C8H8, K7C8I6

Conserved Domains (6) summary

smart00135
Location:553 → 595

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:354 → 388

EGF_CA; Calcium-binding EGF-like domain

pfam00057
Location:195 → 231

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:529 → 569

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

cl00104
Location:278 → 308

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam14670
Location:318 → 346

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_024351166.3 → XP_024206934.1 low-density lipoprotein receptor isoform X2

UniProtKB/TrEMBL

K7C8H8

Conserved Domains (6) summary

smart00135
Location:553 → 595

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:354 → 388

EGF_CA; Calcium-binding EGF-like domain

pfam00057
Location:195 → 231

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:529 → 569

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

cl00104
Location:278 → 308

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam14670
Location:318 → 346

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_063801206.1 → XP_063657276.1 low-density lipoprotein receptor isoform X3

UniProtKB/TrEMBL

A0A2J8LW44