VAV1 vav guanine nucleotide exchange factor 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: VAV1provided by VGNC
Official Full Name: vav guanine nucleotide exchange factor 1provided by VGNC
Primary source: VGNC:VGNC:2419
Locus tag: CK820_G0054312
See related: Ensembl:ENSPTRG00000010378
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	20	NC_072418.2 (9135320..9223526)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	19	NC_072417.1 (9140235..9223569)

Chromosome 20 - NC_072418.2 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_063801080.1 → XP_063657150.1 proto-oncogene vav isoform X3
XM_016934840.4 → XP_016790329.1 proto-oncogene vav isoform X1

UniProtKB/TrEMBL

A0A2I3T0Z6, A0A2J8IPX8, A0A6D2X6C5, H2QF58

Related

ENSPTRP00000017657.4

Conserved Domains (7) summary

cd10405
Location:665 → 767

SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins

cd11976
Location:786 → 839

SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein

cd11979
Location:596 → 658

SH3_VAV1_1; First Src homology 3 domain of VAV1 protein

cd00160
Location:195 → 371

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:385 → 508

PH_Vav; Vav pleckstrin homology (PH) domain

cd21262
Location:2 → 121

CH_VAV1; calponin homology (CH) domain found in VAV1 protein

cd20867
Location:510 → 566

C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein
XM_016934842.4 → XP_016790331.1 proto-oncogene vav isoform X2

UniProtKB/TrEMBL

A0A2I3T0Z6