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FECH ferrochelatase [ Pan troglodytes (chimpanzee) ]

Gene ID: 455437, updated on 3-Apr-2024

Summary

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Official Symbol
FECHprovided by VGNC
Official Full Name
ferrochelataseprovided by VGNC
Primary source
VGNC:VGNC:5169
Locus tag
CK820_G0011396
See related
Ensembl:ENSPTRG00000010045
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 17 NC_072415.2 (67614286..67652014, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 18 NC_072416.1 (66550731..66588447, complement)

Chromosome 17 - NC_072415.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134808617 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 Neighboring gene one cut homeobox 2 Neighboring gene uncharacterized LOC134808618 Neighboring gene asparaginyl-tRNA synthetase 1 Neighboring gene ATPase phospholipid transporting 8B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Contribution of a common single-nucleotide polymorphism to the genetic predisposition for erythropoietic protoporphyria. Gouya L, et al. Am J Hum Genet, 2006 Jan. PMID 16385445, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ferrochelatase, mitochondrial
Names
ferrochelatase (protoporphyria)
heme synthase
heme synthetase
protoheme ferro-lyase
NP_001033101.1
XP_016788687.1
XP_016788688.1
XP_016788690.1
XP_016788692.1
XP_016788693.1
XP_054527641.1
XP_054527642.1
XP_054527643.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038012.1 → NP_001033101.1  ferrochelatase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001033101.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ149645
    UniProtKB/Swiss-Prot
    Q3YA36
    UniProtKB/TrEMBL
    K7A567
    Related
    ENSPTRP00000054886.4, ENSPTRT00000062330.4
    Conserved Domains (3) summary
    cd00419
    Location:235 → 372
    Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    cd03411
    Location:69 → 230
    Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    pfam00762
    Location:69 → 389
    Ferrochelatase; Ferrochelatase

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072415.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    67614286..67652014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054671667.2 → XP_054527642.1  ferrochelatase, mitochondrial isoform X5

  2. XM_054671666.2 → XP_054527641.1  ferrochelatase, mitochondrial isoform X3

  3. XM_016933201.4 → XP_016788690.1  ferrochelatase, mitochondrial isoform X4

    UniProtKB/TrEMBL
    K7A567

  4. XM_016933199.4 → XP_016788688.1  ferrochelatase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    K7A567
    Conserved Domains (3) summary
    cd00419
    Location:241 → 366
    Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    cd03411
    Location:75 → 236
    Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    pfam00762
    Location:75 → 375
    Ferrochelatase; Ferrochelatase

  5. XM_016933198.4 → XP_016788687.1  ferrochelatase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A2I3REE8, A0A2J8NDP1, A0A6D2XZB8, K7A567
    Related
    ENSPTRP00000063006.1
    Conserved Domains (1) summary
    pfam00762
    Location:75 → 395
    Ferrochelatase; Ferrochelatase

  6. XM_016933204.4 → XP_016788693.1  ferrochelatase, mitochondrial isoform X6

    UniProtKB/TrEMBL
    H2RB24
    Conserved Domains (1) summary
    pfam00762
    Location:1 → 317
    Ferrochelatase

  7. XM_016933203.4 → XP_016788692.1  ferrochelatase, mitochondrial isoform X6

    UniProtKB/TrEMBL
    H2RB24
    Conserved Domains (1) summary
    pfam00762
    Location:1 → 317
    Ferrochelatase

  8. XM_054671668.2 → XP_054527643.1  ferrochelatase, mitochondrial isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3YA36.1 GenPept UniProtKB/Swiss-Prot:Q3YA36

Gene LinkOut

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