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SMAD2 SMAD family member 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 455407, updated on 3-Apr-2024

Summary

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Official Symbol
SMAD2provided by VGNC
Official Full Name
SMAD family member 2provided by VGNC
Primary source
VGNC:VGNC:5206
Locus tag
CK820_G0011536
See related
Ensembl:ENSPTRG00000043695
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 17 NC_072415.2 (57911265..58000877, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 18 NC_072416.1 (56883560..56980492, complement)

Chromosome 17 - NC_072415.2Genomic Context describing neighboring genes Neighboring gene thiopurine S-methyltransferase pseudogene Neighboring gene uncharacterized LOC107969492 Neighboring gene uncharacterized LOC129137868 Neighboring gene zinc finger and BTB domain containing 7C Neighboring gene uncharacterized LOC104003149 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mothers against decapentaplegic homolog 2
Names
Sma- and Mad-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072415.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    57911265..58000877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054672021.2 → XP_054527996.1  mothers against decapentaplegic homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A2J8NEG3, A0A6D2VSG8, K7CQY5

  2. XM_016933657.3 → XP_016789146.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8NEI3, A0A6D2Y9D5, H2QEH9, K7C8J5
    Related
    ENSPTRP00000062376.1
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  3. XM_063796098.1 → XP_063652168.1  mothers against decapentaplegic homolog 2 isoform X4

  4. XM_063796095.1 → XP_063652165.1  mothers against decapentaplegic homolog 2 isoform X3

  5. XM_016933658.3 → XP_016789147.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8NEI3, A0A6D2Y9D5, H2QEH9, K7C8J5
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  6. XM_063796093.1 → XP_063652163.1  mothers against decapentaplegic homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A2J8NEG3, A0A6D2VSG8, K7CQY5

  7. XM_001149646.7 → XP_001149646.1  mothers against decapentaplegic homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_001149646.1

    UniProtKB/TrEMBL
    A0A2J8NEI3, A0A6D2Y9D5, H2QEH9, K7C8J5
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  8. XM_063796100.1 → XP_063652170.1  mothers against decapentaplegic homolog 2 isoform X4

  9. XM_054672023.2 → XP_054527998.1  mothers against decapentaplegic homolog 2 isoform X3

  10. XM_063796091.1 → XP_063652161.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8NEI3, A0A6D2Y9D5, H2QEH9

  11. XM_063796094.1 → XP_063652164.1  mothers against decapentaplegic homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A2J8NEG3, A0A6D2VSG8, K7CQY5

  12. XM_063796096.1 → XP_063652166.1  mothers against decapentaplegic homolog 2 isoform X3

  13. XM_063796089.1 → XP_063652159.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8NEI3, A0A6D2Y9D5, H2QEH9

  14. XM_063796088.1 → XP_063652158.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8NEI3, A0A6D2Y9D5, H2QEH9

  15. XM_063796092.1 → XP_063652162.1  mothers against decapentaplegic homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A2J8NEG3, A0A6D2VSG8, K7CQY5

  16. XM_063796090.1 → XP_063652160.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8NEI3, A0A6D2Y9D5, H2QEH9

  17. XM_063796097.1 → XP_063652167.1  mothers against decapentaplegic homolog 2 isoform X4

  18. XM_063796101.1 → XP_063652171.1  mothers against decapentaplegic homolog 2 isoform X4

  19. XM_063796099.1 → XP_063652169.1  mothers against decapentaplegic homolog 2 isoform X4

  20. XM_054672020.2 → XP_054527995.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8NEI3, A0A6D2Y9D5, H2QEH9

  21. XM_016933663.3 → XP_016789152.1  mothers against decapentaplegic homolog 2 isoform X4

    Conserved Domains (1) summary
    cd10985
    Location:26 → 216
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
Nucleotide Protein
Heading Accession and Version

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