ROCK1 Rho associated coiled-coil containing protein kinase 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: ROCK1provided by VGNC
Official Full Name: Rho associated coiled-coil containing protein kinase 1provided by VGNC
Primary source: VGNC:VGNC:7330
Locus tag: CK820_G0018554
See related: Ensembl:ENSPTRG00000009904
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as: ROCK-I; p160ROCK
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	17	NC_072415.2 (30793377..30953110, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	18	NC_072416.1 (29718621..29878345, complement)

Chromosome 17 - NC_072415.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

RH65142 (e-PCR)
- UniSTS:88128

RH122410 (e-PCR)
- UniSTS:135280

ROCK1 (e-PCR)
- UniSTS:504235

D18S374E (e-PCR)
- UniSTS:473078

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in actomyosin structure organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cortical actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in embryonic morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell junction assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: rho-associated protein kinase 1

Names: Rho-associated protein kinase 1; p160 ROCK-1; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I

XP_001151982.1

EC 2.7.11.1

XP_016788908.1

EC 2.7.11.1

XP_016788909.1

EC 2.7.11.1

XP_054527969.1

EC 2.7.11.1

XP_063652090.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072415.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

30793377..30953110 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063796020.1 → XP_063652090.1 rho-associated protein kinase 1 isoform X4
XM_016933419.4 → XP_016788908.1 rho-associated protein kinase 1 isoform X2

UniProtKB/TrEMBL

A0A2I3T6I0
XM_001151982.5 → XP_001151982.1 rho-associated protein kinase 1 isoform X1

See identical proteins and their annotated locations for XP_001151982.1

UniProtKB/TrEMBL

A0A2I3T6I0, A0A2J8MPD5, A0A6D2WAN4, H2QEB3

Related

ENSPTRP00000016847.4

Conserved Domains (5) summary

cd11639
Location:489 → 554

HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1

COG0419
Location:422 → 1027

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd00029
Location:1229 → 1275

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01242
Location:1119 → 1225

PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain

cd05622
Location:2 → 406

STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
XM_016933420.3 → XP_016788909.1 rho-associated protein kinase 1 isoform X3

UniProtKB/TrEMBL

A0A2I3T6I0
XM_054671994.2 → XP_054527969.1 rho-associated protein kinase 1 isoform X5