YES1 YES proto-oncogene 1, Src family tyrosine kinase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: YES1provided by VGNC
Official Full Name: YES proto-oncogene 1, Src family tyrosine kinaseprovided by VGNC
Primary source: VGNC:VGNC:10011
Locus tag: CK820_G0018533
See related: Ensembl:ENSPTRG00000009824
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	17	NC_072415.2 (30107069..30198702)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	18	NC_072416.1 (29032295..29123936)

Chromosome 17 - NC_072415.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

RH68784 (e-PCR)
- UniSTS:49173

STS-R69158 (e-PCR)
- UniSTS:25901

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

D22S1032 (e-PCR)
- UniSTS:58713

STS-M15990 (e-PCR)
- UniSTS:32861

RH65978 (e-PCR)
- UniSTS:19297

RH69573 (e-PCR)
- UniSTS:86460

GDB:196598 (e-PCR)
- UniSTS:155870

RH69080 (e-PCR)
- UniSTS:76525

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase Yes

Names: v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; viral oncogene yes-1 homolog 1

XP_001148240.1

EC 2.7.10.1

EC 2.7.10.2

XP_009432035.1

EC 2.7.10.1

EC 2.7.10.2

XP_009432036.1

EC 2.7.10.1

EC 2.7.10.2

XP_009432037.1

EC 2.7.10.1

EC 2.7.10.2

XP_063651612.1

EC 2.7.10.1

EC 2.7.10.2

XP_063651613.1

EC 2.7.10.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072415.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

30107069..30198702

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009433760.5 → XP_009432035.1 tyrosine-protein kinase Yes isoform X3

See identical proteins and their annotated locations for XP_009432035.1

UniProtKB/TrEMBL

A0A2I3RAZ5, A0A2J8MP97, A0A2J8MP98, A0A6D2WFH5, A0A6D2WSR0, H2QE70

Conserved Domains (3) summary

cd09933
Location:154 → 253

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:94 → 151

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

cd05069
Location:264 → 542

PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
XM_009433761.4 → XP_009432036.1 tyrosine-protein kinase Yes isoform X3

See identical proteins and their annotated locations for XP_009432036.1

UniProtKB/TrEMBL

A0A2I3RAZ5, A0A2J8MP97, A0A2J8MP98, A0A6D2WFH5, A0A6D2WSR0, H2QE70

Conserved Domains (3) summary

cd09933
Location:154 → 253

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:94 → 151

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

cd05069
Location:264 → 542

PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
XM_001148240.6 → XP_001148240.1 tyrosine-protein kinase Yes isoform X3

See identical proteins and their annotated locations for XP_001148240.1

UniProtKB/TrEMBL

A0A2I3RAZ5, A0A2J8MP97, A0A2J8MP98, A0A6D2WFH5, A0A6D2WSR0, H2QE70

Conserved Domains (3) summary

cd09933
Location:154 → 253

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:94 → 151

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

cd05069
Location:264 → 542

PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
XM_009433762.5 → XP_009432037.1 tyrosine-protein kinase Yes isoform X4

See identical proteins and their annotated locations for XP_009432037.1

UniProtKB/TrEMBL

A0A2I3RAZ5, A0A2J8MP98, A0A6D2WFH5

Conserved Domains (3) summary

cd09933
Location:154 → 253

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:94 → 151

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

cl21453
Location:264 → 498

PKc_like; Protein Kinases, catalytic domain
XM_063795542.1 → XP_063651612.1 tyrosine-protein kinase Yes isoform X1

UniProtKB/TrEMBL

A0A2J8MP99
XM_063795543.1 → XP_063651613.1 tyrosine-protein kinase Yes isoform X2