eIF4E1 eukaryotic translation initiation factor 4E1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF4E1provided by FlyBase
Official Full Name: eukaryotic translation initiation factor 4E1provided by FlyBase
Primary source: FLYBASE:FBgn0015218
Locus tag: Dmel_CG4035
See related: AllianceGenome:FB:FBgn0015218
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0260/09; 0587/11; 0589/11; 0919/12; 1004/13; 2; 7238; CBP; CG4035; CT13384; CT39424; CT39426; D-eIF4E; deIF-4E; dEif-4e; deIF4E; dEif4e; Dmel\CG4035; eIF 4E; eif-4e; eif-4E; eIF-4e; eIF-4E; eIF-4E1; eIF-4E2; eIF-4EII; eif4e; eiF4E; eIF4e; eIF4E; Eif4e; Eif4E; EIF4E; eIF4E-1; eIF4E-1/2; eIF4E-2; eIF4EI; eIF4F; elF4E; IF4E; l(3)07238; l(3)67Af; l(3)S025007; l(3)S026009; l(3)S058711; l(3)S091912
Summary: Enables RNA 7-methylguanosine cap binding activity; eukaryotic initiation factor 4G binding activity; and translation initiation factor activity. Involved in RNA metabolic process and translational initiation. Located in cytoplasmic ribonucleoprotein granule; cytosol; and muscle cell postsynaptic specialization. Part of eukaryotic translation initiation factor 4F complex and messenger ribonucleoprotein complex. Is expressed in several structures, including adult heart; embryonic/larval digestive system; extended germ band embryo; presumptive embryonic/larval system; and testis. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E) and EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 67B4-67B4; 3-29 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9399618..9402460, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9392718..9395560, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila Me31B is a Dual eIF4E-Interacting Protein.
Title: Drosophila Me31B is a Dual eIF4E-Interacting Protein.
The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation.
Title: The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
Phosphorylation of 4E-BP1 impairs the competition with eIF4G for eIF4E binding.
Title: Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.
Both eIF4E-1 and eIF4E-3 are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.
Title: Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis.
eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.
Title: 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.
Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.
Title: Cap binding-independent recruitment of eIF4E to cytoplasmic foci.
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.
Title: Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.
eIF4E regulates the sex-specific expression of the master switch gene Sxl.
Title: The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster.
data are consistent with the idea that Parkin and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.
Title: Diminution of eIF4E activity suppresses parkin mutant phenotypes.
These results suggest that the eIF4E-1,2 gene is regulated by Hfp through a mechanism linked to transcription control and 3' splice site selection, which determines the pattern and translation efficiency of eIF4E-1,2 mRNAs.
Title: Half pint couples transcription and splicing of eIF4E-1,2 gene during fly development.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA cap binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic initiation factor 4G binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation at postsynapse, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation at postsynapse, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IDA Inferred from Direct Assay more info	PubMed
involved_in translation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 4F complex	IPI Inferred from Physical Interaction more info	PubMed
part_of eukaryotic translation initiation factor 4F complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in muscle cell postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: eukaryotic translation initiation factor 4E1

Names: CG4035-PA; CG4035-PB; CG4035-PC; CG4035-PD; CG4035-PE; CG4035-PF; CG4035-PG; CG4035-PH; CG4035-PI; cap binding protein; eIF4E1-PA; eIF4E1-PB; eIF4E1-PC; eIF4E1-PD; eIF4E1-PE; eIF4E1-PF; eIF4E1-PG; eIF4E1-PH; eIF4E1-PI; eukaryotic initiation factor 4E; eukaryotic translation initiation factor 4E; lethal(3)67Af

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9399618..9402460 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168333.2 → NP_729480.1 eukaryotic translation initiation factor 4E1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729480.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48598

Related

FBpp0076216

Conserved Domains (1) summary

pfam01652
Location:71 → 228

IF4E; Eukaryotic initiation factor 4E
NM_080090.3 → NP_524829.1 eukaryotic translation initiation factor 4E1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524829.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9

UniProtKB/TrEMBL

M9PBZ9

Related

FBpp0076215

Conserved Domains (1) summary

pfam01652
Location:82 → 239

IF4E; Eukaryotic initiation factor 4E
NM_168335.2 → NP_729482.1 eukaryotic translation initiation factor 4E1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729482.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9

UniProtKB/TrEMBL

M9PBZ9

Related

FBpp0076217

Conserved Domains (1) summary

pfam01652
Location:82 → 239

IF4E; Eukaryotic initiation factor 4E
NM_001274698.1 → NP_001261627.1 eukaryotic translation initiation factor 4E1, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261627.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9

UniProtKB/TrEMBL

M9PBZ9

Conserved Domains (1) summary

pfam01652
Location:82 → 239

IF4E; Eukaryotic initiation factor 4E
NM_168338.2 → NP_729485.1 eukaryotic translation initiation factor 4E1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729485.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9

UniProtKB/TrEMBL

M9PBZ9

Related

FBpp0076219

Conserved Domains (1) summary

pfam01652
Location:82 → 239

IF4E; Eukaryotic initiation factor 4E
NM_168334.1 → NP_729481.1 eukaryotic translation initiation factor 4E1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729481.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9

UniProtKB/TrEMBL

M9PBZ9

Related

FBpp0076218, FBtr0076490

Conserved Domains (1) summary

pfam01652
Location:82 → 239

IF4E; Eukaryotic initiation factor 4E
NM_001274697.1 → NP_001261626.1 eukaryotic translation initiation factor 4E1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261626.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9

UniProtKB/TrEMBL

M9PBZ9

Conserved Domains (1) summary

pfam01652
Location:82 → 239

IF4E; Eukaryotic initiation factor 4E
NM_168336.2 → NP_729483.1 eukaryotic translation initiation factor 4E1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729483.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9

UniProtKB/TrEMBL

M9PBZ9

Related

FBpp0076220

Conserved Domains (1) summary

pfam01652
Location:82 → 239

IF4E; Eukaryotic initiation factor 4E
NM_168337.2 → NP_729484.1 eukaryotic translation initiation factor 4E1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729484.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9

UniProtKB/TrEMBL

M9PBZ9

Related

FBpp0076221

Conserved Domains (1) summary

pfam01652
Location:82 → 239

IF4E; Eukaryotic initiation factor 4E