PRKCA protein kinase C alpha [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: PRKCAprovided by VGNC
Official Full Name: protein kinase C alphaprovided by VGNC
Primary source: VGNC:VGNC:12611
Locus tag: CK820_G0037991
See related: Ensembl:ENSPTRG00000009557
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	19	NC_072417.2 (79290404..79791155)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	17	NC_072415.1 (77474877..77975603)

Chromosome 19 - NC_072417.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

D17S942 (e-PCR), detects polymorphism
- UniSTS:54536

D17S942 (e-PCR), detects polymorphism
- UniSTS:38171

SHGC-57849 (e-PCR)
- UniSTS:76061

SHGC-145007 (e-PCR)
- UniSTS:174372

SHGC-83280 (e-PCR)
- UniSTS:101158

SHGC-148093 (e-PCR)
- UniSTS:176188

Prkca (e-PCR), detects polymorphism
- UniSTS:144193

D17S1291 (e-PCR)
- UniSTS:2892

D17S1524 (e-PCR)
- UniSTS:9824

D17S1318 (e-PCR)
- UniSTS:82047

RH122238 (e-PCR)
- UniSTS:134786

RH122431 (e-PCR)
- UniSTS:135302

D17S1977 (e-PCR)
- UniSTS:36506

GDB:371878 (e-PCR)
- UniSTS:36507

A007G15 (e-PCR)
- UniSTS:46243

PRKCA_2806 (e-PCR)
- UniSTS:463827

D3S4330 (e-PCR)
- UniSTS:474075

RH121658 (e-PCR)
- UniSTS:134398

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein kinase C alpha type

XP_003315734.1

EC 2.7.11.1

EC 2.7.11.13

XP_009431370.1

EC 2.7.11.1

EC 2.7.11.13

XP_016788284.1

EC 2.7.11.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

79290404..79791155

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009433095.5 → XP_009431370.1 protein kinase C alpha type isoform X1

UniProtKB/TrEMBL

A0A2I3THG5

Conserved Domains (4) summary

cd04026
Location:159 → 289

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

smart00220
Location:339 → 597

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05615
Location:328 → 684

STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha

pfam00130
Location:37 → 89

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_003315686.6 → XP_003315734.1 protein kinase C alpha type isoform X2

See identical proteins and their annotated locations for XP_003315734.1

UniProtKB/TrEMBL

A0A2I3THG5, H2QDQ1

Related

ENSPTRP00000016236.6

Conserved Domains (4) summary

cd04026
Location:159 → 289

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

cd05615
Location:328 → 668

STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha

cd20833
Location:35 → 92

C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

cd20836
Location:102 → 155

C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
XM_016932795.3 → XP_016788284.1 protein kinase C alpha type isoform X3

UniProtKB/TrEMBL

A0A2I3THG5

Related

ENSPTRP00000088697.1