STAT3 signal transducer and activator of transcription 3 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: STAT3provided by VGNC
Official Full Name: signal transducer and activator of transcription 3provided by VGNC
Primary source: VGNC:VGNC:9663
Locus tag: CK820_G0038990
See related: Ensembl:ENSPTRG00000009200
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	19	NC_072417.2 (25756913..25831659)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	17	NC_072415.1 (23941485..24016120)

Chromosome 19 - NC_072417.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

STAT3_852 (e-PCR)
- UniSTS:277773

STS-W49595 (e-PCR)
- UniSTS:50200

D1S1423 (e-PCR)
- UniSTS:149619

PMC303343P1 (e-PCR)
- UniSTS:272501

A008U14 (e-PCR)
- UniSTS:53407

D11S3502 (e-PCR)
- UniSTS:152741

PMC317074P1 (e-PCR)
- UniSTS:273070

NoName (e-PCR)
- UniSTS:236743

RH36906 (e-PCR)
- UniSTS:87001

RH102656 (e-PCR)
- UniSTS:96990

D17S1460E (e-PCR)
- UniSTS:150501

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: signal transducer and activator of transcription 3

Names: signal transducer and activator of transcription 3 (acute-phase response factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

25756913..25831659

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001165480.8 → XP_001165480.2 signal transducer and activator of transcription 3 isoform X2

See identical proteins and their annotated locations for XP_001165480.2

UniProtKB/TrEMBL

A0A2I3SFL1, A0A2I3TQ88, A0A2J8KFU9, A0A6D2WYD9

Related

ENSPTRP00000075279.1

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
XM_063798569.1 → XP_063654639.1 signal transducer and activator of transcription 3 isoform X6

UniProtKB/TrEMBL

A0A2J8KFW8, A0A8I3B3S9, K7AN07, K7DE52
XM_063798568.1 → XP_063654638.1 signal transducer and activator of transcription 3 isoform X4

UniProtKB/TrEMBL

A0A2J8KFV1
XM_063798570.1 → XP_063654640.1 signal transducer and activator of transcription 3 isoform X8
XM_009432157.5 → XP_009430432.3 signal transducer and activator of transcription 3 isoform X1
XM_009432160.5 → XP_009430435.3 signal transducer and activator of transcription 3 isoform X5
XM_009432159.5 → XP_009430434.3 signal transducer and activator of transcription 3 isoform X3
XM_009432161.5 → XP_009430436.3 signal transducer and activator of transcription 3 isoform X7
XM_009432158.5 → XP_009430433.2 signal transducer and activator of transcription 3 isoform X2

UniProtKB/TrEMBL

A0A2I3SFL1, A0A2J8KFU9, A0A6D2WYD9
XM_063798566.1 → XP_063654636.1 signal transducer and activator of transcription 3 isoform X6

UniProtKB/TrEMBL

A0A2J8KFW8, A0A8I3B3S9, K7AN07, K7DE52
XM_001165417.8 → XP_001165417.3 signal transducer and activator of transcription 3 isoform X4

UniProtKB/TrEMBL

A0A2J8KFV1
XM_063798567.1 → XP_063654637.1 signal transducer and activator of transcription 3 isoform X8