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GIT1 GIT ArfGAP 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 454549, updated on 29-Mar-2024

Summary

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Official Symbol
GIT1provided by VGNC
Official Full Name
GIT ArfGAP 1provided by VGNC
Primary source
VGNC:VGNC:9301
Locus tag
CK820_G0028497
See related
Ensembl:ENSPTRG00000008952
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 19 NC_072417.2 (37991537..38007640)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 17 NC_072415.1 (36175994..36192097)

Chromosome 19 - NC_072417.2Genomic Context describing neighboring genes Neighboring gene coronin 6 Neighboring gene ankyrin repeat domain 13B Neighboring gene tumor protein p53 inducible protein 13 Neighboring gene sterile alpha motif domain-containing protein 1-like Neighboring gene abhydrolase domain containing 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic vesicle recycling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ARF GTPase-activating protein GIT1
Names
G protein-coupled receptor kinase interacting ArfGAP 1
G protein-coupled receptor kinase interactor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    37991537..38007640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_511377.8 → XP_511377.3  ARF GTPase-activating protein GIT1 isoform X1

    See identical proteins and their annotated locations for XP_511377.3

    UniProtKB/TrEMBL
    A0A2J8LIJ0, A0A2J8LIJ4, A0A6D2W788, H2RDX5
    Related
    ENSPTRP00000059492.1
    Conserved Domains (6) summary
    smart00105
    Location:3 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:123 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:337 → 364
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:649 → 763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:418 → 482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  2. XM_003315546.6 → XP_003315594.1  ARF GTPase-activating protein GIT1 isoform X3

    See identical proteins and their annotated locations for XP_003315594.1

    UniProtKB/TrEMBL
    A0A2I3RZ97, A0A2J8LII8, A0A6D2X5A7, H2QCK6
    Related
    ENSPTRP00000015283.3
    Conserved Domains (6) summary
    smart00105
    Location:3 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:123 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:328 → 355
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:640 → 754
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:409 → 473
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  3. XM_016932108.4 → XP_016787597.1  ARF GTPase-activating protein GIT1 isoform X4

    UniProtKB/TrEMBL
    A0A2J8LIJ4

  4. XM_016932109.4 → XP_016787598.1  ARF GTPase-activating protein GIT1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3RZ97
Nucleotide Protein
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