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PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 454422, updated on 3-Apr-2024

Summary

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Official Symbol
PAFAH1B1provided by VGNC
Official Full Name
platelet activating factor acetylhydrolase 1b regulatory subunit 1provided by VGNC
Primary source
VGNC:VGNC:9502
Locus tag
CK820_G0046788
See related
Ensembl:ENSPTRG00000008551
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as
LIS-1; PAFAHA
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 19 NC_072417.2 (13088036..13176661)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 17 NC_072415.1 (735088..827064, complement)

Chromosome 19 - NC_072417.2Genomic Context describing neighboring genes Neighboring gene methyltransferase 16, RNA N6-adenosine Neighboring gene eukaryotic translation initiation factor 4A1pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC134808845 Neighboring gene clustered mitochondria homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Dorus S, et al. Cell, 2004 Dec 29. PMID 15620360

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables dynein complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule plus-end binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in microtubule organizing center organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nuclear migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retrograde axonal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vesicle transport along microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of microtubule associated complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
platelet-activating factor acetylhydrolase IB subunit alpha
Names
PAF acetylhydrolase 45 kDa subunit
PAF-AH 45 kDa subunit
PAF-AH alpha
PAFAH alpha
lissencephaly-1 protein
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
NP_001029263.1
XP_016785987.1
XP_054525740.1
XP_063654068.1
XP_063654069.1
XP_063654070.1
XP_063654071.1
XP_063654072.1
XP_063654073.1
XP_063654074.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034091.1 → NP_001029263.1  platelet-activating factor acetylhydrolase IB subunit alpha

    See identical proteins and their annotated locations for NP_001029263.1

    Status: PROVISIONAL

    Source sequence(s)
    AY665285
    UniProtKB/Swiss-Prot
    Q5IS43
    UniProtKB/TrEMBL
    A0A2I3SN67
    Related
    ENSPTRP00000078363.1, ENSPTRT00000102460.1
    Conserved Domains (5) summary
    COG2319
    Location:97 → 410
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08513
    Location:9 → 35
    LisH; LisH
    pfam10211
    Location:6 → 80
    Ax_dynein_light; Axonemal dynein light chain
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    13088036..13176661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063798001.1 → XP_063654071.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2J8JL03, A0A6D2X599, H2QBV7

  2. XM_016930498.4 → XP_016785987.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2I3SN67, A0A2J8JL03, A0A6D2X599, H2QBV7
    Related
    ENSPTRP00000014595.3
    Conserved Domains (3) summary
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:10 → 34
    LisH

  3. XM_063798004.1 → XP_063654074.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X2

  4. XM_063798003.1 → XP_063654073.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X2

  5. XM_063797999.1 → XP_063654069.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2J8JL03, A0A6D2X599, H2QBV7

  6. XM_063797998.1 → XP_063654068.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2J8JL03, A0A6D2X599, H2QBV7

  7. XM_054669765.2 → XP_054525740.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2J8JL03, A0A6D2X599, H2QBV7

  8. XM_063798000.1 → XP_063654070.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2J8JL03, A0A6D2X599, H2QBV7

  9. XM_063798002.1 → XP_063654072.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2J8JL03, A0A6D2X599, H2QBV7

RNA

  1. XR_010152717.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5IS43.3 GenPept UniProtKB/Swiss-Prot:Q5IS43

Gene LinkOut

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