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MMP2 matrix metallopeptidase 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 454094, updated on 29-Mar-2024

Summary

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Official Symbol
MMP2provided by VGNC
Official Full Name
matrix metallopeptidase 2provided by VGNC
Primary source
VGNC:VGNC:5839
Locus tag
CK820_G0016667
See related
Ensembl:ENSPTRG00000008123
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 18 NC_072416.2 (53433674..53461177)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 16 NC_072414.1 (53433593..53460627)

Chromosome 18 - NC_072416.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104002625 Neighboring gene uncharacterized LOC112205877 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain small subunit 2 Neighboring gene solute carrier family 6 member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tissue remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
72 kDa type IV collagenase
Names
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
matrix metalloproteinase 2
XP_016785345.1
XP_016785346.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072416.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    53433674..53461177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016929856.3 → XP_016785345.1  72 kDa type IV collagenase isoform X1

    UniProtKB/TrEMBL
    A0A2I3TEQ9, A0A2J8MWS1, A0A6D2XYB6
    Related
    ENSPTRP00000087749.1
    Conserved Domains (4) summary
    smart00059
    Location:342 → 390
    FN2; Fibronectin type 2 domain
    cd00094
    Location:466 → 660
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:118 → 446
    Peptidase_M10; Matrixin
    pfam01471
    Location:70 → 97
    PG_binding_1; Putative peptidoglycan binding domain

  2. XM_016929857.4 → XP_016785346.1  72 kDa type IV collagenase isoform X2

    UniProtKB/TrEMBL
    A0A2J8MWP5, A0A6D2W0F6, H2QB41
    Related
    ENSPTRP00000013860.5
    Conserved Domains (4) summary
    smart00059
    Location:292 → 340
    FN2; Fibronectin type 2 domain
    cd00094
    Location:416 → 610
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:68 → 396
    Peptidase_M10; Matrixin
    pfam01471
    Location:20 → 47
    PG_binding_1; Putative peptidoglycan binding domain

RNA

  1. XR_010152623.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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