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ITGAM integrin subunit alpha M [ Pan troglodytes (chimpanzee) ]

Gene ID: 454069, updated on 13-Apr-2024

Summary

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Official Symbol
ITGAMprovided by VGNC
Official Full Name
integrin subunit alpha Mprovided by VGNC
Primary source
VGNC:VGNC:5826
Locus tag
CK820_G0050589
See related
Ensembl:ENSPTRG00000008042
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 18 NC_072416.2 (35288248..35360752)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 16 NC_072414.1 (35288137..35360648)

Chromosome 18 - NC_072416.2Genomic Context describing neighboring genes Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif containing 72 Neighboring gene pyrin domain containing 1 Neighboring gene integrin subunit alpha X Neighboring gene integrin subunit alpha D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs). Walter NA, et al. J Theor Biol, 2005 Feb 7. PMID 15572059

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin alpha-M
Names
MAC-1 alpha subunit
integrin alpha M
integrin, alpha M (complement component 3 receptor 3 subunit)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001194934.1 → NP_001181863.1  integrin alpha-M precursor

    Status: PROVISIONAL

    Source sequence(s)
    AF340068, JAQQLN020000018
    UniProtKB/TrEMBL
    A0A2J8J555, Q5NKT4
    Conserved Domains (4) summary
    smart00191
    Location:517 → 572
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149 → 324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1130 → 1144
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:615 → 1033
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072416.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    35288248..35360752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016928461.4 → XP_016783950.1  integrin alpha-M isoform X1

    UniProtKB/TrEMBL
    A0A2J8J552, A0A6D2XDK8, H2QB02, Q5NKT4
    Related
    ENSPTRP00000013737.7
    Conserved Domains (4) summary
    smart00191
    Location:516 → 571
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149 → 324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1129 → 1143
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:614 → 1032
    Integrin_alpha2; Integrin alpha

  2. XM_054667981.2 → XP_054523956.1  integrin alpha-M isoform X2

  3. XM_016928462.2 → XP_016783951.1  integrin alpha-M isoform X3

    UniProtKB/TrEMBL
    Q5NKT4

  4. XM_016928463.1 → XP_016783952.1  integrin alpha-M isoform X4

    UniProtKB/TrEMBL
    Q5NKT4
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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