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FURIN furin, paired basic amino acid cleaving enzyme [ Pan troglodytes (chimpanzee) ]

Gene ID: 453652, updated on 3-Apr-2024

Summary

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Official Symbol
FURINprovided by VGNC
Official Full Name
furin, paired basic amino acid cleaving enzymeprovided by VGNC
Primary source
VGNC:VGNC:7766
Locus tag
CK820_G0032356
See related
Ensembl:ENSPTRG00000007461
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 16 NC_072414.2 (82668902..82684126)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 15 NC_072413.1 (82643636..82658860)

Chromosome 16 - NC_072414.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC746953 Neighboring gene BLM RecQ like helicase Neighboring gene small nucleolar RNA SNORD18 Neighboring gene uncharacterized LOC129137252 Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene mannosidase alpha class 2A member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide hormone processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
furin
XP_009428116.1
XP_016782923.1
XP_016782924.1
XP_054523926.1
XP_054523927.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072414.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    82668902..82684126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016927434.3 → XP_016782923.1  furin

    UniProtKB/TrEMBL
    A0A2J8L6G8, A0A2J8L6H9, A0A6D2WY63, H2QA34
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  2. XM_054667951.2 → XP_054523926.1  furin

    UniProtKB/TrEMBL
    A0A2J8L6G8, A0A6D2WY63, H2QA34

  3. XM_009429841.5 → XP_009428116.1  furin

    See identical proteins and their annotated locations for XP_009428116.1

    UniProtKB/TrEMBL
    A0A2J8L6G8, A0A2J8L6H9, A0A6D2WY63, H2QA34
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  4. XM_054667952.2 → XP_054523927.1  furin

    UniProtKB/TrEMBL
    A0A2J8L6G8, A0A6D2WY63, H2QA34

  5. XM_016927435.4 → XP_016782924.1  furin

    UniProtKB/TrEMBL
    A0A2J8L6G8, A0A2J8L6H9, A0A6D2WY63, H2QA34
    Related
    ENSPTRP00000012755.2
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain
Nucleotide Protein
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