PDE8A phosphodiesterase 8A [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: PDE8Aprovided by VGNC
Official Full Name: phosphodiesterase 8Aprovided by VGNC
Primary source: VGNC:VGNC:1899
Locus tag: CK820_G0053345
See related: Ensembl:ENSPTRG00000007408
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	16	NC_072414.2 (76777774..76933941)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	15	NC_072413.1 (76752631..76908795)

Chromosome 16 - NC_072414.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

A008L24 (e-PCR)
- UniSTS:7936

SHGC-35120 (e-PCR)
- UniSTS:68365

RH66263 (e-PCR)
- UniSTS:32271

T02909 (e-PCR)
- UniSTS:54033

STS-AA039638 (e-PCR)
- UniSTS:15141

RH98243 (e-PCR)
- UniSTS:88897

D15S135E (e-PCR)
- UniSTS:81996

STS-R97428 (e-PCR)
- UniSTS:47694

PDE8A_7736 (e-PCR)
- UniSTS:468104

STS-R05505 (e-PCR)
- UniSTS:71314

SGC31715 (e-PCR)
- UniSTS:65734

RH44511 (e-PCR)
- UniSTS:56278

G19611 (e-PCR)
- UniSTS:49637

A001T02 (e-PCR)
- UniSTS:49638

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

XP_001163046.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072414.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

76777774..76933941

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001163046.7 → XP_001163046.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

See identical proteins and their annotated locations for XP_001163046.1

UniProtKB/TrEMBL

A0A2I3RBH2, A0A2J8ITG5, A0A6D2WPX2, H2QA09

Related

ENSPTRP00000012657.4

Conserved Domains (3) summary

COG2202
Location:108 → 324

PAS; PAS domain [Signal transduction mechanisms]

pfam00233
Location:555 → 808

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:226 → 324

PAS_9; PAS domain