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NUMB NUMB endocytic adaptor protein [ Pan troglodytes (chimpanzee) ]

Gene ID: 453014, updated on 3-Apr-2024

Summary

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Gene symbol
NUMB
Gene description
NUMB endocytic adaptor protein
Locus tag
CK820_G0002839
See related
Ensembl:ENSPTRG00000006513
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 15 NC_072413.2 (71249617..71445528, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 14 NC_072412.1 (64545103..64740984, complement)

Chromosome 15 - NC_072413.2Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene papilin, proteoglycan like sulfated glycoprotein Neighboring gene uncharacterized LOC134808374 Neighboring gene protein phosphatase 1 regulatory subunit 14B Neighboring gene HEAT repeat containing 4 Neighboring gene ribosomal oxygenase 1 Neighboring gene uncharacterized LOC107968208 Neighboring gene acyl-CoA thioesterase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in positive regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein numb homolog
Names
numb homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072413.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    71249617..71445528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016926362.4 → XP_016781851.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A2I3S0C7, A0A2J8PJD0, A0A6D2XW92
    Conserved Domains (3) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:247 → 327
    NumbF; NUMB domain
    cl28087
    Location:332 → 513
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  2. XM_016926361.4 → XP_016781850.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A2I3S0C7, A0A2J8PJD0, A0A6D2XW92
    Conserved Domains (3) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:247 → 327
    NumbF; NUMB domain
    cl28087
    Location:332 → 513
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  3. XM_054666103.2 → XP_054522078.1  protein numb homolog isoform X8

  4. XM_016926365.4 → XP_016781854.1  protein numb homolog isoform X4

  5. XM_016926371.4 → XP_016781860.1  protein numb homolog isoform X7

    UniProtKB/TrEMBL
    A0A2J8PJC8, A0A2J8PJF2, A0A803KK36, K7B9S6
    Conserved Domains (3) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:247 → 327
    NumbF; NUMB domain
    cl25764
    Location:385 → 530
    PAT1; Topoisomerase II-associated protein PAT1

  6. XM_063793637.1 → XP_063649707.1  protein numb homolog isoform X6

    UniProtKB/TrEMBL
    K7DR51

  7. XM_016926360.4 → XP_016781849.1  protein numb homolog isoform X2

  8. XM_016926367.4 → XP_016781856.1  protein numb homolog isoform X5

    UniProtKB/TrEMBL
    A0A2I3T8W7, A0A2J8PJD3, A0A2J8PJE8, A0A6D2WW94, A0A6D2WXR1, K7BCD5
    Conserved Domains (3) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258 → 338
    NumbF; NUMB domain
    cl25764
    Location:396 → 541
    PAT1; Topoisomerase II-associated protein PAT1

  9. XM_016926356.4 → XP_016781845.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A2J8PJE4, A0A6D2WST0, H2R3J4, K7DU68
    Conserved Domains (3) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258 → 338
    NumbF; NUMB domain
    cl28087
    Location:343 → 524
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  10. XM_016926363.4 → XP_016781852.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A2I3S0C7, A0A2J8PJD0, A0A6D2XW92
    Conserved Domains (3) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:247 → 327
    NumbF; NUMB domain
    cl28087
    Location:332 → 513
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  11. XM_024348782.3 → XP_024204550.1  protein numb homolog isoform X7

    UniProtKB/TrEMBL
    A0A2J8PJC8, A0A2J8PJF2, A0A803KK36, K7B9S6
    Conserved Domains (3) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:247 → 327
    NumbF; NUMB domain
    cl25764
    Location:385 → 530
    PAT1; Topoisomerase II-associated protein PAT1

  12. XM_054666105.2 → XP_054522080.1  protein numb homolog isoform X8

  13. XM_016926366.4 → XP_016781855.1  protein numb homolog isoform X4

  14. XM_016926368.3 → XP_016781857.1  protein numb homolog isoform X5

    UniProtKB/TrEMBL
    A0A2I3T8W7, A0A2J8PJD3, A0A2J8PJE8, A0A6D2WW94, A0A6D2WXR1, K7BCD5
    Related
    ENSPTRP00000067439.1
    Conserved Domains (3) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258 → 338
    NumbF; NUMB domain
    cl25764
    Location:396 → 541
    PAT1; Topoisomerase II-associated protein PAT1

  15. XM_054666100.2 → XP_054522075.1  protein numb homolog isoform X7

    UniProtKB/TrEMBL
    A0A2J8PJC8, A0A803KK36, K7B9S6

  16. XM_054666104.2 → XP_054522079.1  protein numb homolog isoform X8

  17. XM_054666095.2 → XP_054522070.1  protein numb homolog isoform X4

  18. XM_063793632.1 → XP_063649702.1  protein numb homolog isoform X2

  19. XM_024348781.3 → XP_024204549.1  protein numb homolog isoform X5

    UniProtKB/TrEMBL
    A0A2I3T8W7, A0A2J8PJD3, A0A2J8PJE8, A0A6D2WW94, A0A6D2WXR1, K7BCD5
    Conserved Domains (3) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258 → 338
    NumbF; NUMB domain
    cl25764
    Location:396 → 541
    PAT1; Topoisomerase II-associated protein PAT1

  20. XM_016926357.4 → XP_016781846.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A2J8PJE4, A0A6D2WST0, H2R3J4, K7DU68
    Conserved Domains (3) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258 → 338
    NumbF; NUMB domain
    cl28087
    Location:343 → 524
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  21. XM_054666098.2 → XP_054522073.1  protein numb homolog isoform X5

    UniProtKB/TrEMBL
    A0A2J8PJE8, A0A6D2WXR1, K7BCD5

  22. XM_024348783.3 → XP_024204551.1  protein numb homolog isoform X8

    UniProtKB/TrEMBL
    A0A2J8PJF2
    Conserved Domains (3) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:244 → 324
    NumbF; NUMB domain
    cl25764
    Location:382 → 527
    PAT1; Topoisomerase II-associated protein PAT1

  23. XM_054666097.2 → XP_054522072.1  protein numb homolog isoform X4

  24. XM_054666102.2 → XP_054522077.1  protein numb homolog isoform X7

    UniProtKB/TrEMBL
    A0A2J8PJC8, A0A803KK36, K7B9S6

  25. XM_016926364.4 → XP_016781853.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A2I3S0C7, A0A2J8PJD0, A0A6D2XW92
    Related
    ENSPTRP00000070449.1
    Conserved Domains (3) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:247 → 327
    NumbF; NUMB domain
    cl28087
    Location:332 → 513
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  26. XM_016926359.4 → XP_016781848.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A2J8PJE4, A0A6D2WST0, H2R3J4, K7DU68
    Related
    ENSPTRP00000045621.4
    Conserved Domains (3) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258 → 338
    NumbF; NUMB domain
    cl28087
    Location:343 → 524
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  27. XM_063793638.1 → XP_063649708.1  protein numb homolog isoform X7

    UniProtKB/TrEMBL
    A0A2J8PJC8, A0A803KK36, K7B9S6

  28. XM_063793634.1 → XP_063649704.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A2I3S0C7, A0A2J8PJD0, A0A6D2XW92

  29. XM_063793631.1 → XP_063649701.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A2J8PJE4, A0A6D2WST0, H2R3J4, K7DU68

  30. XM_054666099.2 → XP_054522074.1  protein numb homolog isoform X6

    UniProtKB/TrEMBL
    K7DR51

  31. XM_016926358.4 → XP_016781847.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A2J8PJE4, A0A6D2WST0, H2R3J4, K7DU68
    Conserved Domains (3) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258 → 338
    NumbF; NUMB domain
    cl28087
    Location:343 → 524
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  32. XM_063793633.1 → XP_063649703.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A2I3S0C7, A0A2J8PJD0, A0A6D2XW92

  33. XM_063793639.1 → XP_063649709.1  protein numb homolog isoform X7

    UniProtKB/TrEMBL
    A0A2J8PJC8, A0A803KK36, K7B9S6

  34. XM_054666093.2 → XP_054522068.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A2I3S0C7, A0A2J8PJD0, A0A6D2XW92

  35. XM_063793635.1 → XP_063649705.1  protein numb homolog isoform X4

  36. XM_054666091.2 → XP_054522066.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A2J8PJE4, A0A6D2WST0, H2R3J4, K7DU68

  37. XM_063793640.1 → XP_063649710.1  protein numb homolog isoform X7

    UniProtKB/TrEMBL
    A0A2J8PJC8, A0A803KK36, K7B9S6

  38. XM_054666106.2 → XP_054522081.1  protein numb homolog isoform X8

  39. XM_063793636.1 → XP_063649706.1  protein numb homolog isoform X4

  40. XM_054666094.2 → XP_054522069.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A2I3S0C7, A0A2J8PJD0, A0A6D2XW92
Nucleotide Protein
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