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SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 452897, updated on 29-Mar-2024

Summary

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Official Symbol
SOS2provided by VGNC
Official Full Name
SOS Ras/Rho guanine nucleotide exchange factor 2provided by VGNC
Primary source
VGNC:VGNC:8216
Locus tag
CK820_G0002387
See related
Ensembl:ENSPTRG00000006328
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 15 NC_072413.2 (48135652..48248484, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 14 NC_072412.1 (41404764..41517681, complement)

Chromosome 15 - NC_072413.2Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein encoded by LINC01599 Neighboring gene valosin containing protein lysine methyltransferase Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene microRNA mir-4504 Neighboring gene distal membrane arm assembly component 2 like Neighboring gene cyclin dependent kinase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
son of sevenless homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072413.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    48135652..48248484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016926049.4 → XP_016781538.2  son of sevenless homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A2I3SIR8, A0A2J8PH10, A0A2J8PH14, A0A6D2WUI1, A0A6D2Y8H9, H2R2D5, K7CZM1
    Conserved Domains (5) summary
    smart00229
    Location:595 → 739
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:774 → 1013
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:199 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:70 → 169
    Histone; Core histone H2A/H2B/H3/H4

  2. XM_024348721.3 → XP_024204489.1  son of sevenless homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A2I3SIR8, A0A2J8PH14, A0A6D2WUI1
    Conserved Domains (6) summary
    smart00229
    Location:558 → 702
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:737 → 976
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:199 → 349
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:400 → 506
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam16768
    Location:986 → 1105
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    cl23830
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4

  3. XM_063793337.1 → XP_063649407.1  son of sevenless homolog 2 isoform X5

  4. XM_063793335.1 → XP_063649405.1  son of sevenless homolog 2 isoform X3

  5. XM_024348723.3 → XP_024204491.1  son of sevenless homolog 2 isoform X4

    UniProtKB/TrEMBL
    A0A2I3SIR8, A0A2J8PH14, A0A6D2WUI1
    Conserved Domains (5) summary
    smart00229
    Location:427 → 571
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:606 → 845
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:31 → 218
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:269 → 375
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam16768
    Location:855 → 974
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein

  6. XM_024348724.3 → XP_024204492.1  son of sevenless homolog 2 isoform X6

    UniProtKB/TrEMBL
    A0A2I3SIR8, A0A2J8PH14, A0A6D2WUI1
    Conserved Domains (5) summary
    smart00229
    Location:595 → 739
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:774 → 1013
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:199 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    cl23830
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4
Nucleotide Protein
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