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Prosbeta5 Proteasome beta5 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45269, updated on 5-May-2024

Summary

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Official Symbol
Prosbeta5provided by FlyBase
Official Full Name
Proteasome beta5 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0029134
Locus tag
Dmel_CG12323
See related
AllianceGenome:FB:FBgn0029134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.116; Beta 5 subunit; beta-5; Beta-5; beta5; CG12323; dbeta5; Dmel\CG12323; LD08717; Pros b5; prosbeta5; PSMB5
Summary
Predicted to enable endopeptidase activity. Involved in centrosome cycle and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleoplasm. Part of proteasome core complex. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in JMP syndrome. Orthologous to several human genes including PSMB5 (proteasome 20S subunit beta 5) and PSMB8 (proteasome 20S subunit beta 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
47C1-47C1; 2-63 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10819978..10821178)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6707483..6708683)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene diego Neighboring gene Lsm10 Neighboring gene Ribosomal protein S15Ab Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models. Chocron ES, et al. Sci Adv, 2022 Jun 10. PMID 35675410, Free PMC Article
  2. Neuronal-specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age-related cognitive decline. Munkácsy E, et al. Aging Cell, 2019 Oct. PMID 31334599, Free PMC Article
  3. Aging perturbs 26S proteasome assembly in Drosophila melanogaster. Vernace VA, et al. FASEB J, 2007 Sep. PMID 17413001, Free PMC Article
  4. Amyloid toxicity in a Drosophila Alzheimer's model is ameliorated by autophagy activation. Tsakiri EN, et al. Neurobiol Aging, 2021 Sep. PMID 34062489
  5. The proteasome beta 5 subunit is essential for sexually divergent adaptive homeostatic responses to oxidative stress in D. melanogaster. Pomatto LCD, et al. Free Radic Biol Med, 2020 Nov 20. PMID 32758664, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteasome beta5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster.
    Title: Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activity IC
Inferred by Curator
more info
 PubMed 
enables endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome beta5 subunit
Names
20S proteasome
CG12323-PA
CG12323-PB
Prosbeta5-PA
Prosbeta5-PB
beta5
NP_652014.1
NP_724974.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10819978..10821178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143757.4 → NP_652014.1  proteasome beta5 subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652014.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K148, Q9NHX7
    Related
    FBpp0087320
    Conserved Domains (2) summary
    PTZ00488
    Location:38 → 272
    PTZ00488; Proteasome subunit beta type-5; Provisional
    cd03761
    Location:74 → 261
    proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

  2. NM_165801.2 → NP_724974.1  proteasome beta5 subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724974.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K148, Q9NHX7
    Related
    FBpp0087319
    Conserved Domains (2) summary
    PTZ00488
    Location:38 → 272
    PTZ00488; Proteasome subunit beta type-5; Provisional
    cd03761
    Location:74 → 261
    proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K148 Q7K148
Q9NHX7 Q9NHX7

Gene LinkOut

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