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FLT1 fms related receptor tyrosine kinase 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 452512, updated on 3-Apr-2024

Summary

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Official Symbol
FLT1provided by VGNC
Official Full Name
fms related receptor tyrosine kinase 1provided by VGNC
Primary source
VGNC:VGNC:7287
Locus tag
CK820_G0032576
See related
Ensembl:ENSPTRG00000005743
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 14 NC_072412.2 (27466959..27661970, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 13 NC_072411.1 (22239691..22434420, complement)

Chromosome 14 - NC_072412.2Genomic Context describing neighboring genes Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene elongation factor 1-alpha 1-like Neighboring gene U6 spliceosomal RNA Neighboring gene eukaryotic initiation factor 4A-I-like Neighboring gene proteasome maturation protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
vascular endothelial growth factor receptor 1
Names
fms related tyrosine kinase 1
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
XP_003314141.3
XP_009425065.1
XP_009425066.1
XP_009425067.1
XP_009425070.1
XP_009425072.1
XP_009425073.1
XP_009425074.1
XP_016780602.1
XP_024204257.1
XP_054521122.1
XP_054521123.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072412.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    27466959..27661970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009426791.4 → XP_009425066.1  vascular endothelial growth factor receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3RY59
    Conserved Domains (8) summary
    cd05742
    Location:245 → 327
    Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
    cd07702
    Location:353 → 424
    Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00408
    Location:676 → 738
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:568 → 640
    IG; Immunoglobulin
    smart00410
    Location:237 → 328
    IG_like; Immunoglobulin like
    pfam07679
    Location:661 → 748
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:827 → 1116
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:819 → 1119
    PKc_like; Protein Kinases, catalytic domain

  2. XM_009426790.5 → XP_009425065.1  vascular endothelial growth factor receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A2I3RY59, A0A2J8L5B0, A0A6D2XGC0, H2Q7C8
    Related
    ENSPTRP00000009777.5
    Conserved Domains (6) summary
    cd07702
    Location:353 → 424
    Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00409
    Location:568 → 640
    IG; Immunoglobulin
    pfam07679
    Location:661 → 748
    I-set; Immunoglobulin I-set domain
    cd14207
    Location:819 → 1157
    PTKc_VEGFR1; Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors
    pfam13927
    Location:427 → 539
    Ig_3; Immunoglobulin domain
    cd05742
    Location:245 → 327
    Ig_VEGFR_like; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins

  3. XM_009426792.5 → XP_009425067.1  vascular endothelial growth factor receptor 1 isoform X3

    See identical proteins and their annotated locations for XP_009425067.1

    UniProtKB/TrEMBL
    A0A2I3RY59
    Conserved Domains (6) summary
    cd07702
    Location:216 → 287
    Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00409
    Location:431 → 503
    IG; Immunoglobulin
    pfam07679
    Location:524 → 611
    I-set; Immunoglobulin I-set domain
    cd14207
    Location:682 → 1020
    PTKc_VEGFR1; Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors
    pfam13927
    Location:290 → 402
    Ig_3; Immunoglobulin domain
    cd05742
    Location:108 → 190
    Ig_VEGFR_like; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins

  4. XM_024348489.3 → XP_024204257.1  vascular endothelial growth factor receptor 1 isoform X3

    UniProtKB/TrEMBL
    A0A2I3RY59
    Conserved Domains (6) summary
    cd07702
    Location:216 → 287
    Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00409
    Location:431 → 503
    IG; Immunoglobulin
    pfam07679
    Location:524 → 611
    I-set; Immunoglobulin I-set domain
    cd14207
    Location:682 → 1020
    PTKc_VEGFR1; Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors
    pfam13927
    Location:290 → 402
    Ig_3; Immunoglobulin domain
    cd05742
    Location:108 → 190
    Ig_VEGFR_like; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins

  5. XM_054665147.2 → XP_054521122.1  vascular endothelial growth factor receptor 1 isoform X4

  6. XM_054665148.2 → XP_054521123.1  vascular endothelial growth factor receptor 1 isoform X7

  7. XM_016925113.4 → XP_016780602.1  vascular endothelial growth factor receptor 1 isoform X5

  8. XM_009426795.5 → XP_009425070.1  vascular endothelial growth factor receptor 1 isoform X6

    Conserved Domains (6) summary
    cd05742
    Location:245 → 327
    Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
    cd07702
    Location:353 → 424
    Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00408
    Location:676 → 738
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:237 → 328
    IG_like; Immunoglobulin like
    pfam07679
    Location:661 → 748
    I-set; Immunoglobulin I-set domain
    cl21453
    Location:819 → 903
    PKc_like; Protein Kinases, catalytic domain

  9. XM_009426797.5 → XP_009425072.1  vascular endothelial growth factor receptor 1 isoform X8

    Conserved Domains (6) summary
    cd05742
    Location:245 → 327
    Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
    cd07702
    Location:353 → 424
    Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00408
    Location:676 → 738
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:237 → 328
    IG_like; Immunoglobulin like
    pfam07679
    Location:661 → 748
    I-set; Immunoglobulin I-set domain
    cl21453
    Location:819 → 864
    PKc_like; Protein Kinases, catalytic domain

  10. XM_003314093.5 → XP_003314141.3  vascular endothelial growth factor receptor 1 isoform X9

    UniProtKB/TrEMBL
    A0A2J8L5B1, A0A6D2VX72, K7AVV7

  11. XM_009426798.4 → XP_009425073.1  vascular endothelial growth factor receptor 1 isoform X10

    UniProtKB/TrEMBL
    A0A2I3TTE8, A0A2J8L599, A0A2J8L5B3, A0A6D2XXC8
    Related
    ENSPTRP00000092473.1
    Conserved Domains (4) summary
    cd07702
    Location:353 → 424
    Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00409
    Location:568 → 640
    IG; Immunoglobulin
    pfam13927
    Location:427 → 539
    Ig_3; Immunoglobulin domain
    cl11960
    Location:245 → 327
    Ig; Immunoglobulin domain

  12. XM_009426799.5 → XP_009425074.1  vascular endothelial growth factor receptor 1 isoform X11

    UniProtKB/TrEMBL
    A0A2I3RYL3, A0A2J8L5A3, A0A6D2XUV2
    Related
    ENSPTRP00000069820.1
    Conserved Domains (4) summary
    cd07702
    Location:353 → 424
    Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00409
    Location:143 → 219
    IG; Immunoglobulin
    pfam13927
    Location:427 → 468
    Ig_3; Immunoglobulin domain
    cl11960
    Location:245 → 327
    Ig; Immunoglobulin domain

RNA

  1. XR_010150625.1 RNA Sequence

  2. XR_010150626.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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