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eEF1beta eukaryotic translation elongation factor 1 beta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45249, updated on 4-Apr-2024

Summary

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Official Symbol
eEF1betaprovided by FlyBase
Official Full Name
eukaryotic translation elongation factor 1 betaprovided by FlyBase
Primary source
FLYBASE:FBgn0028737
Locus tag
Dmel_CG6341
See related
AllianceGenome:FB:FBgn0028737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
154264_at; BcDNA.LD24492; BcDNA:LD24492; CG6341; Dmel\CG6341; Ef1beta; EG:EG0003.7; Elf 1 beta
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and organism. Orthologous to human EEF1B2 (eukaryotic translation elongation factor 1 beta 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
53D14-53D14; 2-80 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16868222..16869280)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12755727..12756785)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Dek Neighboring gene P-element somatic inhibitor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis. Gates J, et al. Genetics, 2000 Dec. PMID 11102372, Free PMC Article
  2. Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube. Boyle MJ, et al. Dev Biol, 2010 Oct 1. PMID 20659448, Free PMC Article
  3. Over-expression of a novel nuclear interactor of Suppressor of fused, the Drosophila myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis. Fouix S, et al. Genes Cells, 2003 Nov. PMID 14622141
  4. Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A. Ji S, et al. Proc Natl Acad Sci U S A, 2017 Jun 13. PMID 28484036, Free PMC Article
  5. Introgression in the Drosophila subobscura--D. Madeirensis sister species: evidence of gene flow in nuclear genes despite mitochondrial differentiation. Herrig DK, et al. Evolution, 2014 Mar. PMID 24152112, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation elongation factor 1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation elongation factor 1 beta
Names
CG6341-PB
CG6341-PC
eEF1beta-PB
eEF1beta-PC
elongation facto 1 beta
elongation factor 1 beta
elongation factor 1beta

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16868222..16869280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299577.1 → NP_001286506.1  eukaryotic translation elongation factor 1 beta, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286506.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96827
    UniProtKB/TrEMBL
    A0A0B4LFL3
    Conserved Domains (2) summary
    cd10308
    Location:3 → 62
    GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
    pfam00736
    Location:139 → 222
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  2. NM_080069.4 → NP_524808.3  eukaryotic translation elongation factor 1 beta, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524808.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96827
    UniProtKB/TrEMBL
    A0A0B4LFL3
    Conserved Domains (2) summary
    cd10308
    Location:3 → 62
    GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
    pfam00736
    Location:139 → 222
    EF1_GNE; EF-1 guanine nucleotide exchange domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFL3 A0A0B4LFL3
O96827.3 O96827

Gene LinkOut

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