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GIT2 GIT ArfGAP 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 452227, updated on 3-Apr-2024

Summary

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Official Symbol
GIT2provided by VGNC
Official Full Name
GIT ArfGAP 2provided by VGNC
Primary source
VGNC:VGNC:8597
Locus tag
CK820_G0015941
See related
Ensembl:ENSPTRG00000005433
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 10 NC_072408.2 (116742273..116809132, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 12 NC_072410.1 (115365766..115432622, complement)

Chromosome 10 - NC_072408.2Genomic Context describing neighboring genes Neighboring gene glycolipid transfer protein Neighboring gene trichoplein keratin filament binding Neighboring gene ankyrin repeat domain 13A Neighboring gene chromosome 12 C12orf76 homolog Neighboring gene uncharacterized LOC129136553

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic vesicle recycling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ARF GTPase-activating protein GIT2
Names
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase interactor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    116742273..116809132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054663514.2 → XP_054519489.1  ARF GTPase-activating protein GIT2 isoform X20

  2. XM_016924169.4 → XP_016779658.1  ARF GTPase-activating protein GIT2 isoform X11

    UniProtKB/TrEMBL
    A0A2J8MZ15
    Related
    ENSPTRP00000074563.1
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:558 → 672
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_054663512.2 → XP_054519487.1  ARF GTPase-activating protein GIT2 isoform X8

  4. XM_054663510.2 → XP_054519485.1  ARF GTPase-activating protein GIT2 isoform X6

  5. XM_054663508.2 → XP_054519483.1  ARF GTPase-activating protein GIT2 isoform X3

  6. XM_063784911.1 → XP_063640981.1  ARF GTPase-activating protein GIT2 isoform X13

  7. XM_016924164.4 → XP_016779653.1  ARF GTPase-activating protein GIT2 isoform X4

    UniProtKB/TrEMBL
    A0A2I3SFN4, A0A2J8MZ17, A0A6D2W4X9, K7AK20
    Related
    ENSPTRP00000062238.1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:608 → 722
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  8. XM_016924160.4 → XP_016779649.1  ARF GTPase-activating protein GIT2 isoform X1

    UniProtKB/TrEMBL
    A0A2I3SFN4, A0A2J8MZ21, A0A6D2XID2, H2R2R0, K7C3J8
    Related
    ENSPTRP00000044327.5
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:638 → 752
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  9. XM_063784918.1 → XP_063640988.1  ARF GTPase-activating protein GIT2 isoform X21

  10. XM_063784910.1 → XP_063640980.1  ARF GTPase-activating protein GIT2 isoform X12

  11. XM_024348040.2 → XP_024203808.1  ARF GTPase-activating protein GIT2 isoform X9

    UniProtKB/TrEMBL
    A0A2I3SVH3, A0A2I3TQH8, A0A2J8MZ15, A0A2J8MZ26, A0A2J8MZ29, A0A6D2WYL9, A0A6D2X017
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:587 → 701
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)

  12. XM_054663511.2 → XP_054519486.1  ARF GTPase-activating protein GIT2 isoform X7

  13. XM_063784912.1 → XP_063640982.1  ARF GTPase-activating protein GIT2 isoform X14

  14. XM_054663509.1 → XP_054519484.1  ARF GTPase-activating protein GIT2 isoform X5

  15. XM_016924161.3 → XP_016779650.1  ARF GTPase-activating protein GIT2 isoform X2

    UniProtKB/TrEMBL
    A0A2I3SFN4
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:637 → 751
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:413 → 477
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  16. XM_063784913.1 → XP_063640983.1  ARF GTPase-activating protein GIT2 isoform X15

  17. XM_063784915.1 → XP_063640985.1  ARF GTPase-activating protein GIT2 isoform X17

  18. XM_063784914.1 → XP_063640984.1  ARF GTPase-activating protein GIT2 isoform X16

  19. XM_063784917.1 → XP_063640987.1  ARF GTPase-activating protein GIT2 isoform X19

  20. XM_063784919.1 → XP_063640989.1  ARF GTPase-activating protein GIT2 isoform X22

  21. XM_054663513.2 → XP_054519488.1  ARF GTPase-activating protein GIT2 isoform X10

  22. XM_063784916.1 → XP_063640986.1  ARF GTPase-activating protein GIT2 isoform X18

  23. XM_054663515.2 → XP_054519490.1  ARF GTPase-activating protein GIT2 isoform X24

  24. XM_016924173.3 → XP_016779662.1  ARF GTPase-activating protein GIT2 isoform X23

    UniProtKB/TrEMBL
    A0A2J8MZ07, A0A6D2WUP0, K7BNC8
    Related
    ENSPTRP00000083196.1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 465
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam14203
    Location:246 → 284
    TTRAP; Putative tranposon-transfer assisting protein

RNA

  1. XR_010147757.1 RNA Sequence

  2. XR_008538363.2 RNA Sequence

  3. XR_010147758.1 RNA Sequence

  4. XR_008538362.2 RNA Sequence

  5. XR_008538361.2 RNA Sequence

  6. XR_010147756.1 RNA Sequence

  7. XR_010147759.1 RNA Sequence

Nucleotide Protein
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